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per2.L period circadian regulator 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 394381, updated on 4-Jan-2025

Summary

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Official Symbol
per2.L
Official Full Name
period circadian regulator 2 L homeolog
Primary source
Xenbase:XB-GENE-865597
Locus tag
XELAEV_18027890mg
See related
EnsemblRapid:ENSXLAG00005014720 AllianceGenome:Xenbase:XB-GENE-865597
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
per2; xPer2; per2-A; period2
Summary
Predicted to act upstream of or within rhythmic process. Predicted to be located in cytoplasm and nucleus. Is expressed in anatomical system and ectoderm. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome; advanced sleep phase syndrome 1; alcohol dependence; cocaine dependence; and fetal alcohol spectrum disorder. Orthologous to human PER2 (period circadian regulator 2). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See per2.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
23
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (137698055..137732394, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (126622972..126657332, complement)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene hairy and enhancer of split 6, gene 1 L homeolog Neighboring gene hes family bHLH transcription factor 6 L homeolog Neighboring gene vesicle-associated membrane protein 1-like Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Melanopsins: Localization and Phototransduction in Xenopus laevis Melanophores. Moraes MN, et al. Photochem Photobiol, 2015 Sep-Oct. PMID 26108966
  2. Differential regulation of two period genes in the Xenopus eye. Zhuang M, et al. Brain Res Mol Brain Res, 2000 Oct 20. PMID 11042357

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
period circadian regulator 2 L homeolog
Names
period 2
period circadian clock 2 L homeolog
period homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087629.1 → NP_001081098.1  period circadian regulator 2 L homeolog

    See identical proteins and their annotated locations for NP_001081098.1

    Status: PROVISIONAL

    Source sequence(s)
    AF199499
    UniProtKB/TrEMBL
    A0A974HKM9, Q9DG29
    Related
    ENSXLAP00005043078.1, ENSXLAT00005044146.1
    Conserved Domains (5) summary
    cd00130
    Location:446 → 537
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08226
    Location:1036 → 1106
    DUF1720; Domain of unknown function (DUF1720)
    pfam08447
    Location:449 → 533
    PAS_3; PAS fold
    pfam12114
    Location:1236 → 1409
    Period_C; Period protein 2/3C-terminal region
    cl23807
    Location:1056 → 1112
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    137698055..137732394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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