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ppp2r2b.L protein phosphatase 2 regulatory subunit B, beta L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 394301, updated on 11-Apr-2024

Summary

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Official Symbol
ppp2r2b.L
Official Full Name
protein phosphatase 2 regulatory subunit B, beta L homeolog
Primary source
Xenbase:XB-GENE-946386
Locus tag
XELAEV_18017216mg
See related
EnsemblRapid:ENSXLAG00005029610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
PP2A; ppp2r2b; ppp2r2c; ppp2r2b-a
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Genomic context

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Location:
chromosome: 3L
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (47678598..47882756, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (33301763..33488536, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene transcription elongation regulator 1 L homeolog Neighboring gene G protein-coupled receptor 151 L homeolog Neighboring gene small nucleolar RNA SNORD50 Neighboring gene small nucleolar RNA SNORD50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cDNA cloning of a novel B subunit of Xenopus protein phosphatase 2A and its biological activity in oocytes. Iwashita J, et al. Biochem Biophys Res Commun, 1997 Mar 6. PMID 9125135
  2. Capsaicin inhibits the Wnt/β-catenin signaling pathway by down-regulating PP2A. Park DS, et al. Biochem Biophys Res Commun, 2016 Sep 9. PMID 27318088
  3. Control of timing of embryonic M-phase entry and exit is differentially sensitive to CDK1 and PP2A balance. El Dika M, et al. Int J Dev Biol, 2014. PMID 26154318
  4. Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Mochida S, et al. Science, 2010 Dec 17. PMID 21164013
  5. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Gharbi-Ayachi A, et al. Science, 2010 Dec 17. PMID 21164014

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt/beta-catenin signaling.
    Title: Capsaicin inhibits the Wnt/β-catenin signaling pathway by down-regulating PP2A.
  2. equilibrium between CDK1 and PP2A specifies the timing of M-phase entry and exit and regulates the dynamics of cyclin B degradation upon M-phase exit in Xenopus laevis first embryonic mitosis.
    Title: Control of timing of embryonic M-phase entry and exit is differentially sensitive to CDK1 and PP2A balance.
  3. inhibition of PP2A-B55delta results from Ensa, that is phosphorylated in mitosis by the protein kinase Greatwall; this converts Ensa into specific inhibitor of PP2A-B55delta; this pathway represents a previously unknown element in mitosis control
    Title: Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis.
  4. study describes how Gwl activation results in PP2A inhibition; identified Arpp19 and alpha-Endosulfine that, when phosphorylated by Gwl, associate with and inhibit PP2A promoting mitotic entry
    Title: The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Names
protein phosphatase 2, regulatory subunit B, beta
NP_001080956.1
XP_018106250.2
XP_018106251.1
XP_041440913.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087487.1 → NP_001080956.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

    See identical proteins and their annotated locations for NP_001080956.1

    Status: PROVISIONAL

    Source sequence(s)
    AB000406
    UniProtKB/Swiss-Prot
    A1L3L9, P87345
    Related
    ENSXLAP00005088662.1, ENSXLAT00005090331.1
    Conserved Domains (3) summary
    COG5170
    Location:47 → 463
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:52 → 100
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:46 → 391
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    47678598..47882756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041584979.1 → XP_041440913.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2

    UniProtKB/TrEMBL
    A0A8J1MHB6
    Related
    ENSXLAP00005088887.1, ENSXLAT00005090556.1
    Conserved Domains (2) summary
    COG5170
    Location:14 → 444
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:33 → 81
    7WD40; WD40 repeat [structural motif]

  2. XM_018250761.2 → XP_018106250.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8J0UR55
    Related
    ENSXLAP00005088715.1, ENSXLAT00005090384.1
    Conserved Domains (2) summary
    COG5170
    Location:42 → 458
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:47 → 95
    7WD40; WD40 repeat [structural motif]

  3. XM_018250762.2 → XP_018106251.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3

    UniProtKB/TrEMBL
    A0A1L8GXK3, A0A974DDH7
    Related
    ENSXLAP00005088560.1, ENSXLAT00005090229.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L3L9.2 GenPept UniProtKB/Swiss-Prot:A1L3L9

Gene LinkOut

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