fosab v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fosabprovided by ZNC
Official Full Name: v-fos FBJ murine osteosarcoma viral oncogene homolog Abprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031222-4
See related: Ensembl:ENSDARG00000031683 AllianceGenome:ZFIN:ZDB-GENE-031222-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fos; cb1065; zgc:77885
Summary: Contributes to double-stranded DNA binding activity. Acts upstream of or within cardiac muscle tissue regeneration; hematopoietic stem cell differentiation; and multicellular organismal response to stress. Predicted to be active in nucleus. Is expressed in several structures, including epidermis; head; hematopoietic system; nervous system; and pronephric duct. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	20	NC_133195.1 (49906616..49908729, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (46552311..46554424, complement)

Chromosome 20 - NC_133195.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.
Title: Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.
These results demonstrate the feasibility of immunofluorescence-based methods in the analysis of neuronal activation in the zebrafish brain, and reinforce the utility of the zebrafish in behavioral neuroscience research.
Title: A Simple Method for Immunohistochemical Staining of Zebrafish Brain Sections for c-fos Protein Expression.
the precise temporal modulation of the miR-101a/fosab genetic axis is crucial for coordinating CM proliferation and scar tissue removal during zebrafish heart regeneration
Title: Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration.
Aversive odors and attractive cues activate fos expression in subsets of cells in the olfactory bulb.
Title: Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle tissue regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: v-fos FBJ murine osteosarcoma viral oncogene homolog Ab

Names: c-fos

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205569.1 → NP_991132.1 v-fos FBJ murine osteosarcoma viral oncogene homolog Ab

See identical proteins and their annotated locations for NP_991132.1

Status: PROVISIONAL

Source sequence(s)

BC065466

UniProtKB/TrEMBL

A0A8N1TWB7, Q6P0S4

Related

ENSDARP00000043297.6, ENSDART00000043298.8

Conserved Domains (1) summary

cd14721
Location:113 → 174

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain