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sars2 seryl-tRNA synthetase 2, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 394154, updated on 19-Nov-2025
Official Symbol
sars2provided by ZNC
Official Full Name
seryl-tRNA synthetase 2, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1616
See related
Ensembl:ENSDARG00000102736 AllianceGenome:ZFIN:ZDB-GENE-040426-1616
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SerRS2; zgc:66345
Summary
Predicted to enable serine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Predicted to act upstream of or within seryl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See sars2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 15 NC_133190.1 (16672081..16697541)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 15 NC_007126.7 (14642641..14667105)

Chromosome 15 - NC_133190.1Genomic Context describing neighboring genes Neighboring gene si:dkey-260j18.2 Neighboring gene F-box protein 46 Neighboring gene solute carrier family 5 member 2 Neighboring gene prolyl 4-hydroxylase, alpha polypeptide III Neighboring gene uncharacterized LOC141377754

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC66345

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in seryl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine--tRNA ligase, mitochondrial
NP_957473.1
XP_073778986.1
XP_073778987.1
XP_073778988.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201179.2 → NP_957473.1  serine--tRNA ligase, mitochondrial

    See identical proteins and their annotated locations for NP_957473.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055610
    UniProtKB/TrEMBL
    A0A8M3B0U6, Q7SXG8
    Related
    ENSDARP00000140088.1, ENSDART00000172482.2
    Conserved Domains (3) summary
    PRK05431
    Location:58 → 494
    PRK05431; seryl-tRNA synthetase; Provisional
    cd00770
    Location:185 → 486
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    cl12057
    Location:58 → 172
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133190.1 Reference GRCz12tu Primary Assembly

    Range
    16672081..16697541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073922885.1 → XP_073778986.1  serine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M3B0U6

  2. XM_073922886.1 → XP_073778987.1  serine--tRNA ligase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8M3B0U6

  3. XM_073922887.1 → XP_073778988.1  serine--tRNA ligase, mitochondrial isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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