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ARHGAP5 Rho GTPase activating protein 5 [ Homo sapiens (human) ]

Gene ID: 394, updated on 7-Dec-2018

Summary

Official Symbol
ARHGAP5provided by HGNC
Official Full Name
Rho GTPase activating protein 5provided by HGNC
Primary source
HGNC:HGNC:675
See related
Ensembl:ENSG00000100852 MIM:602680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GFI2; p190-B; RhoGAP5; p190BRhoGAP
Summary
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 21.1), brain (RPKM 17.8) and 25 other tissues See more
Orthologs

Genomic context

See ARHGAP5 in Genome Data Viewer
Location:
14q12
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (32072588..32159728)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (32545664..32628934)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2313 Neighboring gene uncharacterized LOC105370440 Neighboring gene ARHGAP5 antisense RNA 1 (head to head) Neighboring gene RNA, U6 small nuclear 7 Neighboring gene RNA, U6 small nuclear 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • RAC1 signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    RAC1 signaling pathway, organism-specific biosystem
    RAC1 signaling pathway
  • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RhoA activity, organism-specific biosystem
    Regulation of RhoA activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity TAS
Traceable Author Statement
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH2 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 5
Names
growth factor independent 2
p100 RasGAP-associated p105 protein
p105 RhoGAP
rho-type GTPase-activating protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030055.2NP_001025226.1  rho GTPase-activating protein 5 isoform a

    See identical proteins and their annotated locations for NP_001025226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL045112, AL161665, BC050059
    Consensus CDS
    CCDS32062.1
    UniProtKB/Swiss-Prot
    Q13017
    Related
    ENSP00000371897.1, ENST00000345122.7
    Conserved Domains (4) summary
    smart00441
    Location:429481
    FF; Contains two conserved F residues
    cd04373
    Location:12601444
    RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
    pfam16512
    Location:260338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cl21455
    Location:31246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001173.2NP_001164.2  rho GTPase-activating protein 5 isoform b

    See identical proteins and their annotated locations for NP_001164.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is one aa shorter compared to isoform a.
    Source sequence(s)
    AL045112, AL161665, CA945100
    Consensus CDS
    CCDS45095.1
    UniProtKB/Swiss-Prot
    Q13017
    Conserved Domains (4) summary
    smart00441
    Location:429481
    FF; Contains two conserved F residues
    cd04373
    Location:12591443
    RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
    pfam16512
    Location:260338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cl21455
    Location:31246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    32072588..32159728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267636.4XP_005267693.1  rho GTPase-activating protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005267693.1

    UniProtKB/Swiss-Prot
    Q13017
    Conserved Domains (4) summary
    smart00441
    Location:429481
    FF; Contains two conserved F residues
    cd04373
    Location:12601444
    RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
    pfam16512
    Location:260338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cl21455
    Location:31246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_017021288.1XP_016876777.1  rho GTPase-activating protein 5 isoform X2

    UniProtKB/Swiss-Prot
    Q13017
    Related
    ENSP00000452222.1, ENST00000556611.5
    Conserved Domains (4) summary
    smart00441
    Location:429481
    FF; Contains two conserved F residues
    cd04373
    Location:12591443
    RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
    pfam16512
    Location:260338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cl21455
    Location:31246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005267635.4XP_005267692.1  rho GTPase-activating protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005267692.1

    UniProtKB/Swiss-Prot
    Q13017
    Related
    ENSP00000441692.2, ENST00000539826.6
    Conserved Domains (4) summary
    smart00441
    Location:429481
    FF; Contains two conserved F residues
    cd04373
    Location:12601444
    RhoGAP_p190; RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and ...
    pfam16512
    Location:260338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cl21455
    Location:31246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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