lipca lipase, hepatic a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lipcaprovided by ZNC
Official Full Name: lipase, hepatic aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1361
See related: Ensembl:ENSDARG00000053476 AllianceGenome:ZFIN:ZDB-GENE-040426-1361
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lipc; zgc:64081
Summary: Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase A1 activity. Acts upstream of or within response to hormone. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including heart; integument; lens; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (30392705..30406479)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (30121555..30135329)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables apolipoprotein binding	IBA Inferred from Biological aspect of Ancestor more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables lipase activity	IEA Inferred from Electronic Annotation more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hepatic triacylglycerol lipase

NP_957316.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201022.1 → NP_957316.1 hepatic triacylglycerol lipase precursor

See identical proteins and their annotated locations for NP_957316.1

Status: PROVISIONAL

Source sequence(s)

BC053243

UniProtKB/TrEMBL

Q7T359

Related

ENSDARP00000069990.3, ENSDART00000075508.5

Conserved Domains (3) summary

TIGR03230
Location:44 → 488

lipo_lipase; lipoprotein lipase

cd00707
Location:54 → 344

Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

cd01758
Location:351 → 485

PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...