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prkcbb protein kinase C, beta b [ Danio rerio (zebrafish) ]

Gene ID: 393953, updated on 17-May-2023

Summary

Official Symbol
prkcbbprovided by ZNC
Official Full Name
protein kinase C, beta bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1178
See related
Ensembl:ENSDARG00000022254 AllianceGenome:ZFIN:ZDB-GENE-040426-1178
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
PKC-B; Prkcb; prkcb1; zgc:63591
Summary
Predicted to enable several functions, including androgen receptor binding activity; histone kinase activity (H3-T6 specific); and nuclear receptor coactivator activity. Acts upstream of or within blood coagulation and embryonic hemopoiesis. Predicted to be located in nucleus. Is expressed in brain; retinal neural layer; and somite border. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See prkcbb in Genome Data Viewer
Location:
chromosome: 3
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (35005703..35266057)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (34876222..35136544)
103 previous assembly Zv9 (GCF_000002035.4) 3 NC_007114.5 (35090958..35351353)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene fatty acid-binding protein, heart-like Neighboring gene carbonic anhydrase Xb Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Neighboring gene calcium channel, voltage-dependent, gamma subunit 3b Neighboring gene retinoblastoma binding protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC63591

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone H3T6 kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear androgen receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nuclear receptor coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in post-translational protein modification ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein kinase C beta type
Names
PKC-beta
protein kinase C, beta 1
NP_957272.1
XP_005164062.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200978.1NP_957272.1  protein kinase C beta type

    See identical proteins and their annotated locations for NP_957272.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055154
    UniProtKB/Swiss-Prot
    Q7SY24
    Related
    ENSDARP00000038918.6, ENSDART00000029451.7
    Conserved Domains (4) summary
    cd04026
    Location:158288
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:339597
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05616
    Location:338660
    STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
    pfam00130
    Location:3688
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    35005703..35266057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164005.4XP_005164062.1  protein kinase C beta type isoform X1

    UniProtKB/TrEMBL
    A0A8M2BB79
    Related
    ENSDARP00000155856.1, ENSDART00000181163.1
    Conserved Domains (4) summary
    cd04026
    Location:158288
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:339597
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:342661
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:3688
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)