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ercc2 excision repair cross-complementation group 2 [ Danio rerio (zebrafish) ]

Gene ID: 393900, updated on 13-Jul-2025
Official Symbol
ercc2provided by ZNC
Official Full Name
excision repair cross-complementation group 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-997
See related
Ensembl:ENSDARG00000021985 AllianceGenome:ZFIN:ZDB-GENE-040426-997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
XPD; zgc:56365
Summary
Predicted to enable DNA helicase activity and damaged DNA binding activity. Acts upstream of or within endodermal digestive tract morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; female organism; gonad; male organism; and precaudal vertebra. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See ercc2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 15 NC_133190.1 (26146819..26159160, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23680018..23692359, complement)

Chromosome 15 - NC_133190.1Genomic Context describing neighboring genes Neighboring gene creatine kinase, muscle b Neighboring gene kinesin light chain 3 Neighboring gene zgc:154093 Neighboring gene zinc finger CCCH-type containing 4

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Markers

Clone Names

  • MGC56365

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 5'-3' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endodermal digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hair cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
general transcription and DNA repair factor IIH helicase subunit XPD
Names
excision repair cross-complementing rodent repair deficiency, complementation group 2
NP_957220.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200926.2NP_957220.2  general transcription and DNA repair factor IIH helicase subunit XPD

    See identical proteins and their annotated locations for NP_957220.2

    Status: VALIDATED

    Source sequence(s)
    EH550017, EH589655, EH607129, JBMGRA010000015
    UniProtKB/TrEMBL
    F1Q5E7, H8ZIW8
    Related
    ENSDARP00000114026.1, ENSDART00000141618.2
    Conserved Domains (4) summary
    smart00488
    Location:8278
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:542686
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:7708
    rad3; DNA repair helicase (rad3)
    pfam06777
    Location:270413
    HBB; Helical and beta-bridge domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133190.1 Reference GRCz12tu Primary Assembly

    Range
    26146819..26159160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_012390427.1 RNA Sequence