ercc2 excision repair cross-complementation group 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ercc2provided by ZNC
Official Full Name: excision repair cross-complementation group 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-997
See related: Ensembl:ENSDARG00000021985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: XP; XPD; zgc:56365
Orthologs: human mouse all

Genomic context

Location:: chromosome: 15

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (23680018..23692359, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (23744753..23757094, complement)
103	previous assembly	Zv9 (GCF_000002035.4)	15	NC_007126.5 (23033564..23045907, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the regulation and expression of XPD
Title: Cloning, characterization and analysis of the 5' regulatory region of zebrafish xpd gene.
The zebrafish cDNA encoding xpd was isolated and examined its spatial-temporal expression during early development as well as its tissue distribution in adult zebrafish.
Title: Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

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Markers

fb20h11.y1 (e-PCR)
- UniSTS:190295

fc39e05.x1 (e-PCR)
- UniSTS:193755

Homology

Homologs of the ercc2 gene: The ercc2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 277 organisms have orthologs with human gene ercc2
Orthologs

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
DNA binding	IEA Inferred from Electronic Annotation more info
DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA helicase activity	IEA Inferred from Electronic Annotation more info
damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
helicase activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEA Inferred from Electronic Annotation more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
nucleotide-excision repair, DNA duplex unwinding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleotide-excision repair, DNA incision	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to UV	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: general transcription and DNA repair factor IIH helicase subunit XPD

Names: excision repair cross-complementing rodent repair deficiency, complementation group 2

NP_957220.2

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200926.2 → NP_957220.2 general transcription and DNA repair factor IIH helicase subunit XPD

See identical proteins and their annotated locations for NP_957220.2

Status: VALIDATED

Source sequence(s)

CR855332, EH550017, EH589655, EH607129

UniProtKB/TrEMBL

F1Q5E7

Related

ENSDARP00000114026.1, ENSDART00000141618.2

Conserved Domains (4) summary

smart00488
Location:8 → 278

DEXDc2; DEAD-like helicases superfamily

smart00491
Location:542 → 686

HELICc2; helicase superfamily c-terminal domain

TIGR00604
Location:7 → 708

rad3; DNA repair helicase (rad3)

pfam06777
Location:270 → 413

HBB; Helical and beta-bridge domain