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tubg1 tubulin, gamma 1 [ Danio rerio (zebrafish) ]

Gene ID: 393882, updated on 16-Jun-2026
Official Symbol
tubg1provided by ZNC
Official Full Name
tubulin, gamma 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-836
See related
Ensembl:ENSDARG00000015610 AllianceGenome:ZFIN:ZDB-GENE-040426-836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tubgl; zgc:55894
Summary
Predicted to enable GTP binding activity and microtubule nucleator activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Predicted to act upstream of or within cytoplasmic microtubule organization. Predicted to be located in microtubule. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in blastomere; oocyte stage III; and oocyte stage V. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG1 (tubulin gamma 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See tubg1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 3 NC_133178.1 (35926616..35949452, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 3 NC_007114.7 (37059806..37082618, complement)

Chromosome 3 - NC_133178.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141381244 Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H3 Neighboring gene reticulophagy regulator family member 3 Neighboring gene PSMC3 interacting protein Neighboring gene MAX dimerization protein MLX

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. γ-Tubulin small complex formation is essential for early zebrafish embryogenesis. Pouchucq L, et al. Mech Dev, 2018 Dec. PMID 30426927
  2. Changes of gamma-tubulin expression and distribution in the zebrafish (Danio rerio) ovary, oocyte and embryo. Liu J, et al. Gene Expr Patterns, 2008 Apr. PMID 18243062
  3. A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. Sadler KC, et al. Development, 2005 Aug. PMID 16000385
  4. tubg1 Somatic Mutants Show Tubulinopathy-Associated Neurodevelopmental Phenotypes in a Zebrafish Model. Cark O, et al. Mol Neurobiol, 2025 Mar. PMID 39215931
  5. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC55894, MGC174841
Preferred Names
tubulin gamma-1 chain

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320515.1 → NP_001307444.1  tubulin gamma-1 chain isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JBMGRA010000003
    UniProtKB/TrEMBL
    A0A8M1P8D3, A0ACM8QF77, B0JZL0
    Related
    ENSDARP00000101618.1, ENSDART00000110716.3
    Conserved Domains (2) summary
    cd02188
    Location:3 → 231
    gamma_tubulin; The gamma-tubulin family
    pfam00091
    Location:4 → 214
    Tubulin; Tubulin/FtsZ family, GTPase domain

  2. NM_200908.2 → NP_957202.1  tubulin gamma-1 chain isoform 1

    See identical proteins and their annotated locations for NP_957202.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    EH487910, EH600327, JBMGRA010000003
    UniProtKB/TrEMBL
    A0A8M1PDN4, A0ACM8Q045, Q7ZVM5
    Related
    ENSDARP00000016775.8, ENSDART00000026701.9
    Conserved Domains (1) summary
    cd02188
    Location:3 → 435
    gamma_tubulin; The gamma-tubulin family

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133178.1 Reference GRCz12tu Primary Assembly

    Range
    35926616..35949452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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