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LCP2 lymphocyte cytosolic protein 2 [ Homo sapiens (human) ]

Gene ID: 3937, updated on 5-Aug-2022


Official Symbol
LCP2provided by HGNC
Official Full Name
lymphocyte cytosolic protein 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000043462 MIM:601603; AllianceGenome:HGNC:6529
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD81; SLP76; SLP-76
This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]
Broad expression in bone marrow (RPKM 53.7), appendix (RPKM 44.7) and 19 other tissues See more
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Genomic context

See LCP2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (170246233..170297777, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (170785090..170836631, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (169673237..169724781, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1187 Neighboring gene Sharpr-MPRA regulatory region 15284 Neighboring gene chromosome 5 open reading frame 58 Neighboring gene uncharacterized LOC100128059 Neighboring gene long intergenic non-protein coding RNA 1366

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Immunodeficiency 81
MedGen: C5543540 OMIM: 619374 GeneReviews: Not available
not available

EBI GWAS Catalog

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2; SLP76) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of SLP76 by siRNA inhibits HIV-1 infection in MT4 cells and PBMCs PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of lymphocyte cytosolic protein 2 (LCP2, SLP76) in human B cells PubMed
env Lck is recuited to a virological synapse (VS) interface and is highly colocalized with gp120 when cells interact with gp120+ICAM-1 bilayers, leading to activate ZAP70, LAT, SLP76, and PLCgamma PubMed
Nef nef The association of HIV-1 Nef with Vav1, Pak2, and Nck1 is greatly reduced in SLP76-deficient T cells. SLP-76 associates with Nef and modulates actin cytoskeletal reorganization PubMed
nef HIV-1 Nef inhibits colocalization of activated ZAP70 with SLP76 in microclusters (MCs) PubMed
nef HIV-1 Nef potently inhibits formation of SLP76-containing microclusters (MCs) and causes disruption of the SLP76-containing MCs proliferation and translocation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
involved_in immune response TAS
Traceable Author Statement
more info
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
involved_in mast cell activation IEA
Inferred from Electronic Annotation
more info
involved_in positive regulation of protein kinase activity IEP
Inferred from Expression Pattern
more info
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
part_of TCR signalosome IDA
Inferred from Direct Assay
more info
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
located_in cytosol IDA
Inferred from Direct Assay
more info
located_in cytosol TAS
Traceable Author Statement
more info
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
lymphocyte cytosolic protein 2
76 kDa tyrosine phosphoprotein
SH2 domain-containing leukocyte protein of 76 kDa
SLP-76 tyrosine phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005565.5NP_005556.1  lymphocyte cytosolic protein 2

    See identical proteins and their annotated locations for NP_005556.1

    Status: REVIEWED

    Source sequence(s)
    AC034199, AW291566, BC016618, BY995095, DB116470, U20158
    Consensus CDS
    Q13094, Q53XV4
    ENSP00000046794.5, ENST00000046794.10
    Conserved Domains (3) summary
    SAM_SLP76; SAM domain of SLP76 subfamily
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    170246233..170297777 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417171.1XP_047273127.1  lymphocyte cytosolic protein 2 isoform X1

Alternate T2T-CHM13v2.0


  1. NC_060929.1 Alternate T2T-CHM13v2.0

    170785090..170836631 complement
    GenBank, FASTA, Sequence Viewer (Graphics)