aanat1 arylalkylamine N-acetyltransferase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aanat1provided by ZNC
Official Full Name: arylalkylamine N-acetyltransferase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040329-1
See related: Ensembl:ENSDARG00000036567 AllianceGenome:ZFIN:ZDB-GENE-040329-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73074
Summary: Enables acetyltransferase activity. Predicted to be involved in circadian rhythm and response to light stimulus. Predicted to be active in cytoplasm. Is expressed in brain; epiphysis; ovary; and retina. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (23616889..23619413, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (18518970..18521494, complement)
103	previous assembly	Zv9 (GCF_000002035.4)	6	NC_007117.5 (22265935..22268517, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In constant darkness, the rhythmic expression of retinal aanat2 persisted while the aanat1 rhythm disappeared
Title: Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock.

Submit: New GeneRIF Correction

General gene information

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Homology

Homologs of the aanat1 gene: The aanat1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 142 organisms have orthologs with zebrafish gene aanat1
Orthologs

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables aralkylamine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables aralkylamine N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: serotonin N-acetyltransferase

Names: aanat1a

NP_956998.1

EC 2.3.1.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200704.1 → NP_956998.1 serotonin N-acetyltransferase

See identical proteins and their annotated locations for NP_956998.1

Status: PROVISIONAL

Source sequence(s)

BC059448

UniProtKB/TrEMBL

Q6PC75, Q6V7J8

Related

ENSDARP00000053125.5, ENSDART00000053126.7

Conserved Domains (2) summary

COG0456
Location:30 → 200

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:82 → 171

Acetyltransf_1; Acetyltransferase (GNAT) family