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aanat1 arylalkylamine N-acetyltransferase 1 [ Danio rerio (zebrafish) ]

Gene ID: 393677, updated on 11-Jun-2025
Official Symbol
aanat1provided by ZNC
Official Full Name
arylalkylamine N-acetyltransferase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040329-1
See related
Ensembl:ENSDARG00000036567 AllianceGenome:ZFIN:ZDB-GENE-040329-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73074
Summary
Enables acetyltransferase activity. Predicted to be involved in circadian rhythm and response to light stimulus. Predicted to act upstream of or within melatonin biosynthetic process and rhythmic process. Predicted to be active in cytoplasm. Is expressed in brain; epiphysis; ovary; and retina. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
human mouse all
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See aanat1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (21999230..22001754, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (23616889..23619413, complement)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438678 Neighboring gene uncharacterized LOC137490194 Neighboring gene ubiquitin-conjugating enzyme E2O Neighboring gene sb:cb92

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock. Appelbaum L, et al. J Mol Endocrinol, 2006 Apr. PMID 16595704
  2. Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene-9-bisphenol in zebrafish (Danio rerio). Mi P, et al. J Pineal Res, 2019 Jan. PMID 30269372
  3. Melatonin is required for the circadian regulation of sleep. Gandhi AV, et al. Neuron, 2015 Mar 18. PMID 25754820, Free PMC Article
  4. A possible new role for fish retinal serotonin-N-acetyltransferase-1 (AANAT1): Dopamine metabolism. Zilberman-Peled B, et al. Brain Res, 2006 Feb 16. PMID 16427617
  5. Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice. Lee JH, et al. ACS Omega, 2024 Oct 29. PMID 39493976, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In constant darkness, the rhythmic expression of retinal aanat2 persisted while the aanat1 rhythm disappeared
    Title: Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock.
Submit: New GeneRIF Correction

Homology

Clone Names

  • MGC73074

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables aralkylamine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aralkylamine N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within melatonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serotonin N-acetyltransferase
Names
aanat1a
NP_956998.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200704.1 → NP_956998.1  serotonin N-acetyltransferase

    See identical proteins and their annotated locations for NP_956998.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059448
    UniProtKB/TrEMBL
    Q6PC75, Q6V7J8
    Related
    ENSDARP00000053125.5, ENSDART00000053126.7
    Conserved Domains (2) summary
    COG0456
    Location:30 → 200
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:82 → 171
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    21999230..22001754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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