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ldlrb low density lipoprotein receptor b [ Danio rerio (zebrafish) ]

Gene ID: 393460, updated on 7-Apr-2025

Summary

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Official Symbol
ldlrbprovided by ZNC
Official Full Name
low density lipoprotein receptor bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1254
See related
Ensembl:ENSDARG00000026759 AllianceGenome:ZFIN:ZDB-GENE-040426-1254
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63759
Summary
Predicted to enable hormone binding activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See ldlrb in Genome Data Viewer
Location:
chromosome: 6
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (103006..110222)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (84955..91262)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene crystallin, gamma M4 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4b Neighboring gene adaptor related protein complex 1 subunit mu 2 Neighboring gene cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. DHCR7 Expression Predicts Poor Outcomes and Mortality From Sepsis. Guirgis FW, et al. Crit Care Explor, 2023 Jun. PMID 37332366, Free PMC Article
  2. CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations. Höijer I, et al. Nat Commun, 2022 Feb 2. PMID 35110541, Free PMC Article
  3. Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Sun W, et al. Ecotoxicol Environ Saf, 2023 Jul 1. PMID 37201426
  4. Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish. Cho HJ, et al. Dis Model Mech, 2019 May 23. PMID 31043432, Free PMC Article
  5. A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Xue Y, et al. Cell Rep, 2019 Apr 30. PMID 31042481

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC63759

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
low density lipoprotein receptor b; low-density lipoprotein receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    103006..110222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356726.2 → XP_017212215.1  low-density lipoprotein receptor

    UniProtKB/TrEMBL
    A0A8M6Z1D1
    Related
    ENSDARP00000126428.1, ENSDART00000151899.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200488.1: Suppressed sequence

    Description
    NM_200488.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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