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hao2 hydroxyacid oxidase 2 (long chain) [ Danio rerio (zebrafish) ]

Gene ID: 393455, updated on 5-Jul-2025
Official Symbol
hao2provided by ZNC
Official Full Name
hydroxyacid oxidase 2 (long chain)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1239
See related
Ensembl:ENSDARG00000027992 AllianceGenome:ZFIN:ZDB-GENE-040426-1239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63690
Summary
Predicted to enable (S)-2-hydroxy-acid oxidase activity. Predicted to be located in peroxisome. Predicted to be active in peroxisomal matrix. Is expressed in lens; liver; pronephric duct; solid lens vesicle; and yolk syncytial layer. Orthologous to human HAO2 (hydroxyacid oxidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See hao2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 9 NC_133184.1 (22762137..22779950)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21146804..21164617)

Chromosome 9 - NC_133184.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141376109 Neighboring gene T-box transcription factor 15 Neighboring gene tryptophanyl tRNA synthetase 2, mitochondrial Neighboring gene si:rp71-68n21.9 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Zebrafish krüppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages. Li IC, et al. PLoS One, 2011. PMID 21687630, Free PMC Article
  2. Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine. Yang MJ, et al. Virulence, 2020 Dec. PMID 32316833, Free PMC Article
  3. Insights Into the Peroxisomal Protein Inventory of Zebrafish. Kamoshita M, et al. Front Physiol, 2022. PMID 35295584, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC63690

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables (S)-2-hydroxy-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (S)-2-hydroxy-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
2-Hydroxyacid oxidase 2
NP_001417842.1
NP_956777.2
XP_005167602.1
XP_073767863.1
XP_073767864.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430913.1 → NP_001417842.1  2-Hydroxyacid oxidase 2

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000009
    UniProtKB/TrEMBL
    A0A8M2BEY4, F1QCD8, F1R8D5, Q7SXX8

  2. NM_200483.3 → NP_956777.2  2-Hydroxyacid oxidase 2

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000009
    UniProtKB/TrEMBL
    A0A8M2BEY4, F1QCD8, F1R8D5, Q7SXX8
    Related
    ENSDARP00000037427.4, ENSDART00000035428.6

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133184.1 Reference GRCz12tu Primary Assembly

    Range
    22762137..22779950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073911762.1 → XP_073767863.1  2-Hydroxyacid oxidase 2 isoform X1

    UniProtKB/TrEMBL
    Q7SXX8

  2. XM_005167545.5 → XP_005167602.1  2-Hydroxyacid oxidase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BEY4, F1QCD8, F1R8D5, Q7SXX8
    Conserved Domains (2) summary
    cd02809
    Location:7 → 349
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:14 → 353
    FMN_dh; FMN-dependent dehydrogenase

  3. XM_073911763.1 → XP_073767864.1  2-Hydroxyacid oxidase 2 isoform X3

RNA

  1. XR_012384914.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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