arhgap4a Rho GTPase activating protein 4a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arhgap4aprovided by ZNC
Official Full Name: Rho GTPase activating protein 4aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1229
See related: Ensembl:ENSDARG00000039265 AllianceGenome:ZFIN:ZDB-GENE-040426-1229
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63672
Summary: Predicted to be involved in negative regulation of cell migration. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Orthologous to human ARHGAP4 (Rho GTPase activating protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (24989387..25015614)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (25062846..25089070)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in cell development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho GTPase activating protein 4; rho GTPase-activating protein 4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200444.1 → NP_956738.1 rho GTPase-activating protein 4a

See identical proteins and their annotated locations for NP_956738.1

Status: PROVISIONAL

Source sequence(s)

BC054931

UniProtKB/TrEMBL

Q7SYB9

Related

ENSDARP00000134224.2, ENSDART00000172299.2

Conserved Domains (3) summary

cd07656
Location:27 → 252

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cd11956
Location:704 → 758

SH3_srGAP4; Src homology 3 domain of Slit-Robo GTPase Activating Protein 4

cd04383
Location:471 → 655

RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

24989387..25015614

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162155.4 → XP_005162212.1 rho GTPase activating protein 4 isoform X1

See identical proteins and their annotated locations for XP_005162212.1

UniProtKB/TrEMBL

A0A0R4IFP1, A0A8M2B900, F1QFY0

Related

ENSDARP00000121347.1, ENSDART00000145307.2

Conserved Domains (3) summary

cd07656
Location:27 → 252

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cd11956
Location:704 → 758

SH3_srGAP4; Src homology 3 domain of Slit-Robo GTPase Activating Protein 4

cd04383
Location:471 → 655

RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...