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ints6l integrator complex subunit 6 like [ Danio rerio (zebrafish) ]

Gene ID: 393406, updated on 9-Sep-2025
Official Symbol
ints6lprovided by ZNC
Official Full Name
integrator complex subunit 6 likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1150
See related
Ensembl:ENSDARG00000017931 AllianceGenome:ZFIN:ZDB-GENE-040426-1150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ints6; ddx26b; zgc:63527
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Orthologous to several human genes including INTS6L (integrator complex subunit 6 like). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See ints6l in Genome Data Viewer
Location:
chromosome: 14
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (36076345..36120009)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (31566489..31611068)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141377545 Neighboring gene motile sperm domain containing 1 Neighboring gene membrane magnesium transporter 1 Neighboring gene solute carrier family 9 member A6a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis. Kapp LD, et al. PLoS Genet, 2013 Oct. PMID 24204286, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC63527

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II transcription initiation surveillance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of INTAC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
integrator complex subunit 6
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
int6

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200434.2 → NP_956728.1  integrator complex subunit 6

    See identical proteins and their annotated locations for NP_956728.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054905
    UniProtKB/Swiss-Prot
    Q7SYD9
    Related
    ENSDARP00000026435.5, ENSDART00000002684.8
    Conserved Domains (2) summary
    cd00198
    Location:4 → 131
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam15300
    Location:810 → 870
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    36076345..36120009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358997.4 → XP_017214486.1  integrator complex subunit 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z212

RNA

  1. XR_012389407.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SYD9.1 GenPept UniProtKB/Swiss-Prot:Q7SYD9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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