U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ggt1a gamma-glutamyltransferase 1a [ Danio rerio (zebrafish) ]

Gene ID: 393387, updated on 9-Mar-2023

Summary

Official Symbol
ggt1aprovided by ZNC
Official Full Name
gamma-glutamyltransferase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1388
See related
Ensembl:ENSDARG00000023526 AllianceGenome:ZFIN:ZDB-GENE-040426-1388
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ggt1; zgc:64172
Summary
Predicted to enable glutathione hydrolase activity and peptidyltransferase activity. Predicted to be involved in several processes, including peptide metabolic process; response to estradiol; and response to tumor necrosis factor. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in lens and solid lens vesicle. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to human GGT1 (gamma-glutamyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ggt1a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (40041828..40075983, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (40008716..40042209, complement)
103 previous assembly Zv9 (GCF_000002035.4) 8 NC_007119.5 (41995118..42028629, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene aspartate beta-hydroxylase domain containing 2 Neighboring gene gamma-glutamyltransferase 5a Neighboring gene leucine rich repeat containing 75Ba Neighboring gene glutathione peroxidase 8 (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Clone Names

  • MGC64172

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glutathione catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
gamma-glutamyltransferase 1a; gamma-glutamyltranspeptidase 1
Names
gamma-glutamyltransferase 1
NP_956709.1
XP_017212782.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200415.1NP_956709.1  gamma-glutamyltransferase 1a

    See identical proteins and their annotated locations for NP_956709.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054631
    UniProtKB/TrEMBL
    A0A8N7V022, Q7T2A1
    Related
    ENSDARP00000037959.4, ENSDART00000036280.5
    Conserved Domains (1) summary
    pfam01019
    Location:1484
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    40041828..40075983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357293.2XP_017212782.1  gamma-glutamyltranspeptidase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YZQ0