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clec16a C-type lectin domain containing 16A [ Danio rerio (zebrafish) ]

Gene ID: 393184, updated on 9-Sep-2025
Official Symbol
clec16aprovided by ZNC
Official Full Name
C-type lectin domain containing 16Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-951
See related
Ensembl:ENSDARG00000038094 AllianceGenome:ZFIN:ZDB-GENE-040426-951
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56230
Summary
Acts upstream of or within regulation of mitophagy. Predicted to be active in Golgi apparatus. Predicted to colocalize with late endosome. Human ortholog(s) of this gene implicated in Addison's disease; multiple sclerosis; rheumatoid arthritis; and type 1 diabetes mellitus. Orthologous to human CLEC16A (C-type lectin domain containing 16A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See clec16a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 3 NC_133178.1 (25563811..25645085, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26823788..26904873, complement)

Chromosome 3 - NC_133178.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141381204 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Q Neighboring gene suppressor of cytokine signaling 1a Neighboring gene Dexi homolog (mouse) Neighboring gene class II, major histocompatibility complex, transactivator

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development. O'Sullivan LA, et al. J Immunol, 2011 Apr 15. PMID 21421851
  2. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
  3. CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment. Smits DJ, et al. Hum Genet, 2023 Mar. PMID 36538041, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.
    Title: CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC56230

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuolar transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
protein CLEC16A
Names
C-type lectin domain family 16, member A

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133178.1 Reference GRCz12tu Primary Assembly

    Range
    25563811..25645085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163918.5 → XP_005163975.1  protein CLEC16A isoform X2

    UniProtKB/TrEMBL
    A0A8M2BB67
    Related
    ENSDARP00000129343.1, ENSDART00000156150.3
    Conserved Domains (1) summary
    pfam09758
    Location:49 → 196
    FPL; uncharacterized conserved protein

  2. XM_073944522.1 → XP_073800623.1  protein CLEC16A isoform X4

  3. XM_005163916.5 → XP_005163973.1  protein CLEC16A isoform X1

    UniProtKB/TrEMBL
    A0A8M2BBF3
    Conserved Domains (1) summary
    pfam09758
    Location:49 → 196
    FPL; uncharacterized conserved protein

  4. XM_068218015.2 → XP_068074116.1  protein CLEC16A isoform X3

    UniProtKB/TrEMBL
    A0AB32TH44

  5. XM_073944523.1 → XP_073800624.1  protein CLEC16A isoform X6

  6. XM_073944525.1 → XP_073800626.1  protein CLEC16A isoform X8

  7. XM_068218017.2 → XP_068074118.1  protein CLEC16A isoform X5

    UniProtKB/TrEMBL
    A0AB32TFK4

  8. XM_073944524.1 → XP_073800625.1  protein CLEC16A isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200215.1: Suppressed sequence

    Description
    NM_200215.1: This RefSeq was permanently suppressed because there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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