nelfb negative elongation factor complex member B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nelfbprovided by ZNC
Official Full Name: negative elongation factor complex member Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-765
See related: Ensembl:ENSDARG00000035505 AllianceGenome:ZFIN:ZDB-GENE-040426-765
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NELF-B; cobra1; cobra2; bZ1O1.4; fe01e12; zgc:55628; wu:fe01e12
Summary: Predicted to enable translation elongation factor activity. Acts upstream of or within positive regulation of hematopoietic stem cell differentiation and regulation of granulocyte differentiation. Predicted to be located in nucleus. Predicted to be part of NELF complex. Orthologous to human NELFB (negative elongation factor complex member B). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	5	NC_133180.1 (30170578..30182041, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (29548983..29559927, complement)

Chromosome 5 - NC_133180.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW165107 (e-PCR)
- UniSTS:205880

fe01e12.x1 (e-PCR)
- UniSTS:195913

fd08h12.y1 (e-PCR)
- UniSTS:195058

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of granulocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NELF complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: negative elongation factor B

Names: cofactor of BRCA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.