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sepsecs Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [ Danio rerio (zebrafish) ]

Gene ID: 393123, updated on 23-Apr-2026
Official Symbol
sepsecsprovided by ZNC
Official Full Name
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-859
See related
Ensembl:ENSDARG00000033861 AllianceGenome:ZFIN:ZDB-GENE-040426-859
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sla/lpl; zgc:55980
Summary
Predicted to enable tRNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to act upstream of or within conversion of seryl-tRNAsec to selenocys-tRNAsec and translation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See sepsecs in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 7 NC_133182.1 (77091907..77111107, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71437555..71455839, complement)

Chromosome 7 - NC_133182.1Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase/endoribonuclease IRE1-like Neighboring gene leucine-rich repeat LGI family, member 2a Neighboring gene aconitase 1, soluble Neighboring gene leucine-rich melanocyte differentiation-associated protein

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Characterization of human gene encoding SLA/LP autoantigen and its conserved homologs in mouse, fish, fly, and worm. Wang CX, et al. World J Gastroenterol, 2006 Feb 14. PMID 16521218, Free PMC Article
  2. Sex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation. Benner MJ, et al. Physiol Genomics, 2013 Aug 1. PMID 23737534, Free PMC Article
  3. Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. Encinas P, et al. BMC Genomics, 2010 Sep 27. PMID 20875106, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC55980

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables O-phosphoseryl-tRNA(Sec) selenium transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables O-phosphoseryl-tRNA(Sec) selenium transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec IEA
Inferred from Electronic Annotation
more info
  
involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in selenocysteine incorporation IEA
Inferred from Electronic Annotation
more info
  
involved_in selenocysteine incorporation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
O-phosphoseryl-tRNA(Sec) selenium transferase
Names
UGA suppressor tRNA-associated protein homolog
sec synthase
selenocysteine synthase
selenocysteinyl-tRNA(Sec) synthase
sep-tRNA:Sec-tRNA synthase
soluble liver antigen/liver pancreas antigen, like
NP_956448.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200154.1 → NP_956448.1  O-phosphoseryl-tRNA(Sec) selenium transferase

    See identical proteins and their annotated locations for NP_956448.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044561
    UniProtKB/Swiss-Prot
    Q803A7
    Related
    ENSDARP00000042491.5, ENSDART00000042492.7
    Conserved Domains (1) summary
    TIGR03531
    Location:12 → 458
    selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133182.1 Reference GRCz12tu Primary Assembly

    Range
    77091907..77111107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_012382321.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q803A7.1 GenPept UniProtKB/Swiss-Prot:Q803A7

Gene LinkOut

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