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LBP lipopolysaccharide binding protein [ Homo sapiens (human) ]

Gene ID: 3929, updated on 25-Oct-2020

Summary

Official Symbol
LBPprovided by HGNC
Official Full Name
lipopolysaccharide binding proteinprovided by HGNC
Primary source
HGNC:HGNC:6517
See related
Ensembl:ENSG00000129988 MIM:151990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPIFD2
Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]
Expression
Restricted expression toward liver (RPKM 139.3) See more
Orthologs

Genomic context

See LBP in Genome Data Viewer
Location:
20q11.23
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (38346482..38377013)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (36974814..37005653)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene KIAA1755 Neighboring gene uncharacterized LOC149684 Neighboring gene bactericidal permeability increasing protein Neighboring gene Sharpr-MPRA regulatory region 13566 Neighboring gene small nucleolar RNA, H/ACA box 71B Neighboring gene small nucleolar RNA host gene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of chronic periodontitis in a general German population.
GeneReviews: Not available
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of lipopolysaccharide binding protein (LBP) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22233

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipopeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipopolysaccharide binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
acute-phase response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular defense response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipoteichoic acid IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IC
Inferred by Curator
more info
PubMed 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
leukocyte chemotaxis involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide transport IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
macromolecule localization IDA
Inferred from Direct Assay
more info
PubMed 
macrophage activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
opsonization IC
Inferred by Curator
more info
PubMed 
opsonization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of macrophage activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of respiratory burst involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 4 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lipopolysaccharide-binding protein
Names
BPI fold containing family D, member 2
LPS-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034239.1 RefSeqGene

    Range
    5072..35603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004139.5NP_004130.2  lipopolysaccharide-binding protein precursor

    See identical proteins and their annotated locations for NP_004130.2

    Status: REVIEWED

    Source sequence(s)
    AF105067, AL391095, BC022256
    Consensus CDS
    CCDS13304.1
    UniProtKB/Swiss-Prot
    P18428
    UniProtKB/TrEMBL
    Q8TCF0
    Related
    ENSP00000217407.2, ENST00000217407.3
    Conserved Domains (2) summary
    smart00328
    Location:33256
    BPI1; BPI/LBP/CETP N-terminal domain
    pfam02886
    Location:241478
    LBP_BPI_CETP_C; LBP / BPI / CETP family, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    38346482..38377013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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