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AGMO alkylglycerol monooxygenase [ Homo sapiens (human) ]

Gene ID: 392636, updated on 9-Jun-2025
Official Symbol
AGMOprovided by HGNC
Official Full Name
alkylglycerol monooxygenaseprovided by HGNC
Primary source
HGNC:HGNC:33784
See related
Ensembl:ENSG00000187546 MIM:613738; AllianceGenome:HGNC:33784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM195
Summary
The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]
Expression
Biased expression in liver (RPKM 8.7), small intestine (RPKM 2.1) and 4 other tissues See more
Orthologs
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See AGMO in Genome Data Viewer
Location:
7p21.2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (15117223..15562015, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (15250047..15695255, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (15239942..15601640, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase beta Neighboring gene uncharacterized LOC105375164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:14779612-14780128 Neighboring gene general transcription factor IIIA pseudogene 5 Neighboring gene uncharacterized LOC124901592 Neighboring gene Sharpr-MPRA regulatory region 14752 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:15557538-15558346 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:15586656-15587206 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:15587207-15587755 Neighboring gene uncharacterized LOC124901591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:15638304-15638834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:15638835-15639363 Neighboring gene uncharacterized LOC105375166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:15724672-15725504 Neighboring gene long intergenic non-protein coding RNA 2587 Neighboring gene mesenchyme homeobox 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ16237, MGC131748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glyceryl-ether monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glyceryl-ether monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glyceryl-ether monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables glyceryl-ether monooxygenase activity TAS
Traceable Author Statement
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ether lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in membrane lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
alkylglycerol monooxygenase
Names
glyceryl-ether monooxygenase
transmembrane protein 195
NP_001004320.1
XP_006715793.1
XP_006715794.1
XP_011513704.1
XP_016867693.1
XP_047276320.1
XP_054214175.1
XP_054214176.1
XP_054214177.1
XP_054214178.1
XP_054214179.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004320.2NP_001004320.1  alkylglycerol monooxygenase

    See identical proteins and their annotated locations for NP_001004320.1

    Status: REVIEWED

    Source sequence(s)
    AC091789, AK131284
    Consensus CDS
    CCDS34604.1
    UniProtKB/Swiss-Prot
    A4D114, A6NCH5, Q6ZNB7
    UniProtKB/TrEMBL
    X5D773
    Related
    ENSP00000341662.3, ENST00000342526.8
    Conserved Domains (2) summary
    COG3000
    Location:43255
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:120249
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    15117223..15562015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012204.2XP_016867693.1  alkylglycerol monooxygenase isoform X4

  2. XM_011515402.4XP_011513704.1  alkylglycerol monooxygenase isoform X3

    Conserved Domains (2) summary
    COG3000
    Location:43255
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:120249
    FA_hydroxylase; Fatty acid hydroxylase superfamily
  3. XM_006715731.3XP_006715794.1  alkylglycerol monooxygenase isoform X5

    Conserved Domains (2) summary
    COG3000
    Location:43255
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:120249
    FA_hydroxylase; Fatty acid hydroxylase superfamily
  4. XM_006715730.1XP_006715793.1  alkylglycerol monooxygenase isoform X2

    Conserved Domains (2) summary
    COG3000
    Location:43255
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:120249
    FA_hydroxylase; Fatty acid hydroxylase superfamily
  5. XM_047420364.1XP_047276320.1  alkylglycerol monooxygenase isoform X1

RNA

  1. XR_001744759.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    15250047..15695255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358203.1XP_054214178.1  alkylglycerol monooxygenase isoform X4

  2. XM_054358202.1XP_054214177.1  alkylglycerol monooxygenase isoform X3

  3. XM_054358204.1XP_054214179.1  alkylglycerol monooxygenase isoform X5

  4. XM_054358201.1XP_054214176.1  alkylglycerol monooxygenase isoform X2

  5. XM_054358200.1XP_054214175.1  alkylglycerol monooxygenase isoform X1

RNA

  1. XR_008487615.1 RNA Sequence