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Adck5 aarF domain containing kinase 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39260, updated on 6-Jul-2026
Official Symbol
Adck5provided by FlyBase
Official Full Name
aarF domain containing kinase 5provided by FlyBase
Primary source
FLYBASE:FBgn0036142
Locus tag
Dmel_CG7616
See related
AllianceGenome:FB:FBgn0036142
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7616; dADCK5; Dmel\CG7616; FBgn 36142
Summary
Involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Is expressed in adult head. Orthologous to human ADCK5 (aarF domain containing kinase 5). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Adck5 in Genome Data Viewer
Location:
68A9-68A9; 3-34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11169817..11172411)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11162917..11165511)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ALG10 alpha-1,2-glucosyltransferase Neighboring gene wntless Neighboring gene uncharacterized protein Neighboring gene Glucuronyltransferase P

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Functional analysis of Aarf domain-containing kinase 1 in Drosophila melanogaster. Wisidagama DR, et al. Dev Dyn, 2019 Sep. PMID 31175694, Free PMC Article
  2. Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. Yoon W, et al. PLoS Genet, 2019 May. PMID 31125351, Free PMC Article
  3. Modelling the human coenzyme Q deficiency in Drosophila melanogaster. Fernández-Ayala DJM, et al. Free Radic Biol Med, 2025 Mar 16. PMID 39864756
  4. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Goodman RM, et al. Development, 2006 Dec. PMID 17108000
  5. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in lipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
aarF domain containing kinase 5
Names
Adck5-PA
Adck5-PB
CG7616-PA
CG7616-PB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11169817..11172411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140189.3 → NP_648446.1  aarF domain containing kinase 5, isoform A

    See identical proteins and their annotated locations for NP_648446.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B0BNN6, Q9VTG5
    Related
    FBpp0075892
    Conserved Domains (2) summary
    COG0661
    Location:98 → 469
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:144 → 395
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  2. NM_001274776.1 → NP_001261705.1  aarF domain containing kinase 5, isoform B

    See identical proteins and their annotated locations for NP_001261705.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B0BNN6, Q9VTG5
    Conserved Domains (2) summary
    COG0661
    Location:98 → 469
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:144 → 395
    ADCK1-like; aarF domain containing kinase 1 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTG5 Q9VTG5

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