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FAM221B family with sequence similarity 221 member B [ Homo sapiens (human) ]

Gene ID: 392307, updated on 23-Nov-2021

Summary

Official Symbol
FAM221Bprovided by HGNC
Official Full Name
family with sequence similarity 221 member Bprovided by HGNC
Primary source
HGNC:HGNC:30762
See related
Ensembl:ENSG00000204930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf128
Expression
Biased expression in testis (RPKM 2.8) and prostate (RPKM 0.2) See more
Orthologs
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Genomic context

See FAM221B in Genome Data Viewer
Location:
9p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35816391..35829148, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35816388..35828729, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 2 Neighboring gene sperm associated antigen 8 Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene transmembrane protein 8B Neighboring gene olfactory receptor family 13 subfamily E member 1 pseudogene Neighboring gene olfactory receptor family 13 subfamily J member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
protein FAM221B
Names
uncharacterized protein C9orf128

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012446.4NP_001012448.2  protein FAM221B

    See identical proteins and their annotated locations for NP_001012448.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is protein-coding.
    Source sequence(s)
    AL133410, BC146808, BX648702
    Consensus CDS
    CCDS43799.2
    UniProtKB/Swiss-Prot
    A6H8Z2
    Related
    ENSP00000415299.2, ENST00000423537.7
    Conserved Domains (2) summary
    pfam14753
    Location:249393
    DUF4475; Domain of unknown function (DUF4475)
    pfam17061
    Location:12168
    PARM; PARM

RNA

  1. NR_052026.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL133410, BC146808, BX648702
    Related
    ENST00000388950.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35816391..35829148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447542.1XP_024303310.1  protein FAM221B isoform X3

    Conserved Domains (1) summary
    pfam14753
    Location:346
    FAM221; Protein FAM221A/B
  2. XM_024447541.1XP_024303309.1  protein FAM221B isoform X2

    Conserved Domains (1) summary
    pfam14753
    Location:3147
    FAM221; Protein FAM221A/B
  3. XM_006716768.3XP_006716831.1  protein FAM221B isoform X1

    Conserved Domains (2) summary
    pfam14753
    Location:249392
    DUF4475; Domain of unknown function (DUF4475)
    pfam17061
    Location:12168
    PARM; PARM
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