U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

USP17L8 ubiquitin specific peptidase 17 like family member 8 [ Homo sapiens (human) ]

Gene ID: 392188, updated on 13-May-2022

Summary

Official Symbol
USP17L8provided by HGNC
Official Full Name
ubiquitin specific peptidase 17 like family member 8provided by HGNC
Primary source
HGNC:HGNC:37181
See related
Ensembl:ENSG00000237038 AllianceGenome:HGNC:37181
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USP17L10
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene contains an intact open reading frame; however, it is classified as a pseudogene because no transcripts available as of August 2009 are thought to originate from this location, suggesting that this gene does not have a functional promoter. [26 Aug 2009]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See USP17L8 in Genome Data Viewer
Location:
8p23.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7971661..7973253, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7829183..7830775, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene zinc finger protein 705B Neighboring gene defensin beta 108A Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like Neighboring gene family with sequence similarity 66 member E Neighboring gene ubiquitin specific peptidase 17 like family member 3 Neighboring gene defensin beta 109C

Genomic regions, transcripts, and products

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8
Names
ubiquitin specific peptidase 17-like 8
NP_001243801.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256872.1NP_001243801.1  inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8

    See identical proteins and their annotated locations for NP_001243801.1

    Status: INFERRED

    Source sequence(s)
    AC130365
    Consensus CDS
    CCDS78300.1
    UniProtKB/Swiss-Prot
    P0C7I0
    Related
    ENSP00000485306.1, ENST00000527080.1
    Conserved Domains (3) summary
    cd02661
    Location:79373
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:80372
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam04774
    Location:375454
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    7971661..7973253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    880674..882266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012786.1: Suppressed sequence

    Description
    NG_012786.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.