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USP17L8 ubiquitin specific peptidase 17-like family member 8 [ Homo sapiens (human) ]

Gene ID: 392188, updated on 25-May-2017
Official Symbol
USP17L8provided by HGNC
Official Full Name
ubiquitin specific peptidase 17-like family member 8provided by HGNC
Primary source
See related
Ensembl:ENSG00000237038 Vega:OTTHUMG00000165405
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Annotation information
Note: This gene contains an intact open reading frame; however, it is classified as a pseudogene because no transcripts available as of August 2009 are thought to originate from this location, suggesting that this gene does not have a functional promoter. [26 Aug 2009]
Exon count:
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (7971661..7973253, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7829183..7830775, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 705B Neighboring gene defensin beta 108A Neighboring gene family with sequence similarity 66 member E Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like Neighboring gene ubiquitin specific peptidase 17-like family member 3 Neighboring gene family with sequence similarity 90, member A11

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...



Gene Ontology Provided by GOA

Function Evidence Code Pubs
thiol-dependent ubiquitinyl hydrolase activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
protein deubiquitination IEA
Inferred from Electronic Annotation
more info
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
nucleus IEA
Inferred from Electronic Annotation
more info
Preferred Names
inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8
ubiquitin specific peptidase 17-like 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256872.1NP_001243801.1  inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8

    See identical proteins and their annotated locations for NP_001243801.1

    Status: INFERRED

    Source sequence(s)
    Consensus CDS
    ENSP00000485306.1, OTTHUMP00000277924, ENST00000527080.1, OTTHUMT00000383808
    Conserved Domains (3) summary
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    UCH; Ubiquitin carboxyl-terminal hydrolase
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly


  1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

    7971661..7973253 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1


  1. NC_018919.2 Alternate CHM1_1.1

    7894491..7896083 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012786.1: Suppressed sequence

    NG_012786.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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