CG32066 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG32066provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0052066
Locus tag: Dmel_CG32066
See related: AllianceGenome:FB:FBgn0052066
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6487; CG6491; Dmel\CG32066
Summary: Enables small GTPase binding activity. Involved in negative regulation of border follicle cell migration; negative regulation of lamellipodium assembly; and negative regulation of wound healing, spreading of epidermal cells. Located in perivitelline space. Is active in lamellipodium; macropinocytic cup; and pseudopodium. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and synaptic neuropil domain. Orthologous to human CYRIA (CYFIP related Rac1 interactor A) and CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (10640286..10661013, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (10633386..10654113, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in macropinocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in perivitelline space	HDA more info	PubMed
is_active_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed

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