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E(z) Enhancer of zeste [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39203, updated on 9-May-2019

Summary

Official Symbol
E(z)provided by FlyBase
Official Full Name
Enhancer of zesteprovided by FlyBase
Primary source
FLYBASE:FBgn0000629
Locus tag
Dmel_CG6502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6502; Dmel\CG6502; E(Z); E(z)1; Ez; EZ; EZH1/2; EZH2; E[z]; l(3)1902; l(3)67Fa; l(3)B12; l(3)ds12; l(3)SG17; pco; pco/E(z); Su(z)301

Genomic context

See E(z) in Genome Data Viewer
Location:
67E5-67E5; 3-33 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10634575..10638130, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10627675..10631230, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene haywire Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cuticle hydrocarbon biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene silencing NAS
Non-traceable Author Statement
more info
PubMed 
histone H3-K27 methylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K27 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K9 methylation IDA
Inferred from Direct Assay
more info
PubMed 
histone methylation IDA
Inferred from Direct Assay
more info
PubMed 
histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone methylation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
syncytial blastoderm mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin NAS
Non-traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
enhancer of zeste
Names
CG6502-PA
CG6502-PB
CG6502-PC
E(z)-PA
E(z)-PB
E(z)-PC
enhancer of zest
enhancer-of-zeste
polycombeotic

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10634575..10638130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079297.3NP_524021.2  enhancer of zeste, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524021.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42124
    Related
    FBpp0076008, FBtr0076279
    Conserved Domains (3) summary
    smart00317
    Location:626742
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:466740
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00167
    Location:447487
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  2. NM_001144460.3NP_001137932.1  enhancer of zeste, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137932.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42124
    Related
    FBpp0271846, FBtr0273338
    Conserved Domains (3) summary
    smart00317
    Location:626742
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:466740
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00167
    Location:447487
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. NM_001274753.1NP_001261682.1  enhancer of zeste, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261682.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHZ5
    Related
    FBpp0306192, FBtr0334067
    Conserved Domains (3) summary
    smart00317
    Location:631747
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:471745
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    cd00167
    Location:452492
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
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