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SAOUHSC_00714 sensor histidine kinase SaeS [ Staphylococcus aureus subsp. aureus NCTC 8325 ]

Gene ID: 3919341, updated on 6-Oct-2023

Summary

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Gene symbol
SAOUHSC_00714
Gene description
sensor histidine kinase SaeS
Locus tag
SAOUHSC_00714
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Staphylococcus aureus subsp. aureus NCTC 8325 (strain: NCTC 8325, sub-species: aureus)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus
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Genomic context

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Sequence:
NC_007795.1 (699194..700249, complement)

NC_007795.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene response regulator Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007795.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the DNA-binding domain of the response regulator SaeR from Staphylococcus aureus. Fan X, et al. Acta Crystallogr D Biol Crystallogr, 2015 Aug. PMID 26249357
  2. SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. Cue D, et al. PLoS One, 2015. PMID 25853849, Free PMC Article
  3. The extracytoplasmic linker peptide of the sensor protein SaeS tunes the kinase activity required for staphylococcal virulence in response to host signals. Liu Q, et al. PLoS Pathog, 2015 Apr. PMID 25849574, Free PMC Article
  4. Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis. Xiong YQ, et al. J Infect Dis, 2006 Nov 1. PMID 17041853
  5. sae is essential for expression of the staphylococcal adhesins Eap and Emp. Harraghy N, et al. Microbiology (Reading), 2005 Jun. PMID 15941988

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the sensor histidine kinase SaeS (SaeS) has an L18P (T53C in saeS) substitution, which transformed the protein into an ATP-dependent metalloprotease FtsH (FtsH) substrate.
    Title: Rewiring of the FtsH regulatory network by a single nucleotide change in saeS of Staphylococcus aureus.
  2. the crystal structure of the DNA-binding domain of SaeR (SaeR(DBD)) was solved at 2.5 A resolution. The structure reveals that SaeR(DBD) exists as a monomer and has the canonical winged helix-turn-helix module. [SaeR]
    Title: Structure of the DNA-binding domain of the response regulator SaeR from Staphylococcus aureus.
  3. Our results indicate that the function of the linker peptide in SaeS is a highly evolved feature with very optimized amino acid sequences
    Title: The extracytoplasmic linker peptide of the sensor protein SaeS tunes the kinase activity required for staphylococcal virulence in response to host signals.
  4. The SaeS protein is the histidine kinase responsible for phosphorylation of the response regulator SaeR. RNA-Seq results indicated that sae regulates many genes that may affect biofilm formation
    Title: SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Names
sensor histidine kinase SaeS
YP_499273.1
  • sensor histidine kinase SaeS, putative

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007795.1 Reference assembly

    Range
    699194..700249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_499273.1 sensor histidine kinase SaeS [Staphylococcus aureus subsp. aureus NCTC 8325]

    See identical proteins and their annotated locations for YP_499273.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6B0CSW2
    Conserved Domains (1) summary
    COG0642
    Location:23 → 344
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2G2U1.1

Gene LinkOut

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