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LAMP1 lysosomal associated membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 3916, updated on 3-Jun-2018
Official Symbol
LAMP1provided by HGNC
Official Full Name
lysosomal associated membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:6499
See related
Ensembl:ENSG00000185896 MIM:153330; Vega:OTTHUMG00000017380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAMPA; CD107a; LGP120
Summary
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 123.3), thyroid (RPKM 98.8) and 25 other tissues See more
Orthologs
See LAMP1 in Genome Data Viewer
Location:
13q34
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (113297154..113323426)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113951436..113977746)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene cullin 4A Neighboring gene microRNA 8075 Neighboring gene lactate dehydrogenase B pseudogene 1 Neighboring gene growth hormone regulated TBC protein 1 Neighboring gene MAGE-like protein 2 Neighboring gene GRTP1 antisense RNA 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Ab-dependent activation of NK cells to upregulate the expression of CD107a is most robust when the NK cells are stimulated with HIV-1 gp120-coated primary T cells in the presence of HIV-1 infected plasma PubMed
env HIV-1 gp120 co-localizes with LAMP-1 in human plasmacytoid dendritic cells PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 Env co-localizes with LAMP1 in lysosomes PubMed
env LAMP1 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 mutants W614A, S615A, N616A, and S618A downregulates the cellular surface expression of CD107a on NK-cells PubMed
Nef nef HIV-1 Nef sequesters HLA-I A2 and co-localizes with CD63 and LAMP1 markers in late endosomes and lysosomes PubMed
nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of lysosomal-associated membrane protein 1 (CD107a) PubMed
nef The proportion of HIV-1 Nef-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107a+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point PubMed
nef HIV-1 Nef co-localizes with CXCR4, AIP4, NEDD4, CD63/LAMP-1-positive vesicles, and HRS/VPS27-positive ESCRT-0 structures in HeLa cells PubMed
Pr55(Gag) gag Co-localization of HIV-1 Gag virus-like particles in THP-1/CD169YF cells is reduced within CD81+ compartments, but enhanced within CD63+ or LAMP1+ compartments PubMed
gag The proportion of HIV-1 Gag-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point PubMed
gag LAMP-mediated upregulation of HIV-1 LAMP-Gag fusion protein expression is dependent on the LAMP luminal domain, leading to induce LAMP-Gag secretion through exosomes PubMed
gag In human macrophages, HIV-1 Gag proteins co-localize with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments PubMed
gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
gag HIV-1 Gag and viral RNA co-localize with LAMP1 in lysosomes PubMed
gag Gag myristoylation is important for the co-trafficking of HIV-1 RNA and Gag on LAMP-1+ membranes. Gag nucleocapsid mutations lead to a loss of colocalization between LAMP-1 and HIV-1 RNA or Gag PubMed
gag HIV-1 RNA is distributed throughout the cytoplasm in a punctate pattern, at the plasma membrane , and partially co-localizes with both Gag and LAMP-1 in the perinuclear region PubMed
Tat tat HIV-1 Tat upregulates LAMP1 on the surface of primary astrocytes, which is a measurement for lysosomal exocytosis PubMed
Vpr vpr HIV-1 YU-2 or ADA Vpr inhibits LAMP1 recruitment to and maturation of phagosomes in primary human macrophages PubMed
vpr HIV-1 Vpr abrogates co-localization of LAMP1 with HIV-1 MA (p17) (lysosomal targeting) in monocyte-derived macropaphages PubMed
vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of lysosomal-associated membrane protein 1 (CD107a) PubMed
vpu Expression of HIV-1 Vpu induces co-localization of tetherin with early endosome protein EEA-1 or late endosome protein LAMP-1 PubMed
capsid gag HIV-1 CA-stimulated CD8+ T cells upregulate CD107 expression compared to unstimulated cells PubMed
gag In human macrophages, HIV-1 Capsid (p24) co-localizes with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments PubMed
matrix gag HIV-1 MA (p17) colocalizes with LAMP1 (lysosomal targeting) in the absense of Vpr in monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Golgi to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagic cell death IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
granzyme-mediated apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of natural killer cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of organelle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
alveolar lamellar body IEA
Inferred from Electronic Annotation
more info
 
autolysosome IEA
Inferred from Electronic Annotation
more info
 
azurophil granule membrane TAS
Traceable Author Statement
more info
 
cytolytic granule IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with lysosome IDA
Inferred from Direct Assay
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
multivesicular body IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagolysosome membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
lysosome-associated membrane glycoprotein 1
Names
CD107 antigen-like family member A
LAMP-1
lysosome-associated membrane protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005561.3NP_005552.3  lysosome-associated membrane glycoprotein 1 precursor

    See identical proteins and their annotated locations for NP_005552.3

    Status: REVIEWED

    Source sequence(s)
    BC025335, BU849686, DB462451
    Consensus CDS
    CCDS41909.1
    UniProtKB/Swiss-Prot
    P11279
    UniProtKB/TrEMBL
    A0A024RDY3
    Related
    ENSP00000333298.4, OTTHUMP00000018748, ENST00000332556.4, OTTHUMT00000045876
    Conserved Domains (1) summary
    pfam01299
    Location:112417
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    113297154..113323426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537494.2XP_011535796.1  lysosome-associated membrane glycoprotein 1 isoform X1

    Conserved Domains (2) summary
    cd12087
    Location:362392
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam01299
    Location:93398
    Lamp; Lysosome-associated membrane glycoprotein (Lamp)
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