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SPINT4 serine peptidase inhibitor, Kunitz type 4 [ Homo sapiens (human) ]

Gene ID: 391253, updated on 24-Nov-2020

Summary

Official Symbol
SPINT4provided by HGNC
Official Full Name
serine peptidase inhibitor, Kunitz type 4provided by HGNC
Primary source
HGNC:HGNC:16130
See related
Ensembl:ENSG00000149651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPINT3; C20orf137; dJ601O1.1
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SPINT4 in Genome Data Viewer
Location:
20q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (45722347..45725830)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44350988..44354335)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 11 Neighboring gene WAP four-disulfide core domain 10B Neighboring gene WAP four-disulfide core domain 13 Neighboring gene microRNA 3617 Neighboring gene WAP four-disulfide core domain 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 3 Neighboring gene serine peptidase inhibitor, Kunitz type 5, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kunitz-type protease inhibitor 4
Names
epididymis secretory sperm binding protein
serine protease inhibitor, Kunitz type 1
serine protease inhibitor, Kunitz type 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178455.3NP_848550.1  kunitz-type protease inhibitor 4 precursor

    See identical proteins and their annotated locations for NP_848550.1

    Status: VALIDATED

    Source sequence(s)
    AL109656, AW303354, AY372173, CO408459
    Consensus CDS
    CCDS33477.1
    UniProtKB/Swiss-Prot
    Q6UDR6
    Related
    ENSP00000279058.3, ENST00000279058.4
    Conserved Domains (1) summary
    cd00109
    Location:3992
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    45722347..45725830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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