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PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing [ Homo sapiens (human) ]

Gene ID: 390940, updated on 1-Aug-2020

Summary

Official Symbol
PINLYPprovided by HGNC
Official Full Name
phospholipase A2 inhibitor and LY6/PLAUR domain containingprovided by HGNC
Primary source
HGNC:HGNC:44206
See related
Ensembl:ENSG00000234465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 1.9), endometrium (RPKM 1.3) and 25 other tissues See more
Orthologs

Genomic context

See PINLYP in Genome Data Viewer
Location:
19q13.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43576800..43582104)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44080952..44086256)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 575 Neighboring gene X-ray repair cross complementing 1 Neighboring gene immunity related GTPase Q Neighboring gene zinc finger protein 576

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phospholipase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193621.2NP_001180550.2  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
    Source sequence(s)
    AI298189, AK296854, BC071811, DW009999, L34079
    Consensus CDS
    CCDS74385.1
    Related
    ENSP00000479240.1, ENST00000612042.4
    Conserved Domains (1) summary
    cl10471
    Location:27107
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. NM_001193622.1NP_001180551.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001180551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AI298189, BC071811
    Consensus CDS
    CCDS58667.1
    UniProtKB/Swiss-Prot
    A6NC86
    Related
    ENSP00000457623.1, ENST00000562255.5
    Conserved Domains (1) summary
    cl10471
    Location:3888
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. NM_001321124.1NP_001308053.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same protein.
    Source sequence(s)
    AI298189, CN355575, HY005068
    Consensus CDS
    CCDS58667.1
    UniProtKB/Swiss-Prot
    A6NC86
    Related
    ENSP00000457369.1, ENST00000569031.6
    Conserved Domains (1) summary
    cl10471
    Location:3888
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43576800..43582104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526971.2XP_011525273.1  phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X2

    See identical proteins and their annotated locations for XP_011525273.1

    UniProtKB/Swiss-Prot
    A6NC86
    Conserved Domains (1) summary
    cl10471
    Location:3888
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
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