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ACP7 acid phosphatase 7, tartrate resistant (putative) [ Homo sapiens (human) ]

Gene ID: 390928, updated on 1-Jun-2020

Summary

Official Symbol
ACP7provided by HGNC
Official Full Name
acid phosphatase 7, tartrate resistant (putative)provided by HGNC
Primary source
HGNC:HGNC:33781
See related
Ensembl:ENSG00000183760 MIM:610490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPL; PAPL1
Summary
Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in skin (RPKM 2.2), brain (RPKM 0.3) and 1 other tissue See more
Orthologs

Genomic context

See ACP7 in Genome Data Viewer
Location:
19q13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39083011..39112074)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39574945..39602129)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene F-box protein 17 Neighboring gene F-box protein 27 Neighboring gene p21 (RAC1) activated kinase 4 Neighboring gene NCCRP1, F-box associated domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acid phosphatase type 7
Names
iron/zinc purple acid phosphatase-like protein
purple acid phosphatase long form 1
NP_001004318.2
NP_001350616.1
XP_011525268.1
XP_011525269.1
XP_011525271.1
XP_016882296.1
XP_016882297.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004318.3NP_001004318.2  acid phosphatase type 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004318.2

    Status: VALIDATED

    Source sequence(s)
    AC011443, AK131245, BC142613
    Consensus CDS
    CCDS33018.1
    UniProtKB/Swiss-Prot
    Q6ZNF0
    Related
    ENSP00000327557.4, ENST00000331256.10
    Conserved Domains (2) summary
    cd00839
    Location:131429
    MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
    pfam16656
    Location:34124
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
  2. NM_001363687.2NP_001350616.1  acid phosphatase type 7 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011443
    Consensus CDS
    CCDS86764.1
    Related
    ENSP00000470989.1, ENST00000594229.1
    Conserved Domains (2) summary
    pfam16656
    Location:34124
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
    cl13995
    Location:131168
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    39083011..39112074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026807.2XP_016882296.1  acid phosphatase type 7 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZNF0
    Conserved Domains (2) summary
    cd00839
    Location:131429
    MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
    pfam16656
    Location:34124
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
  2. XM_017026808.2XP_016882297.1  acid phosphatase type 7 isoform X5

  3. XM_011526967.3XP_011525269.1  acid phosphatase type 7 isoform X2

    Conserved Domains (3) summary
    cd00839
    Location:131371
    MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
    pfam00149
    Location:135337
    Metallophos; Calcineurin-like phosphoesterase
    pfam16656
    Location:32124
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
  4. XM_011526969.2XP_011525271.1  acid phosphatase type 7 isoform X3

    Conserved Domains (2) summary
    cd00839
    Location:131269
    MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
    pfam16656
    Location:32124
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain
  5. XM_011526966.3XP_011525268.1  acid phosphatase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011525268.1

    UniProtKB/Swiss-Prot
    Q6ZNF0
    Conserved Domains (2) summary
    cd00839
    Location:131429
    MPP_PAPs; purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain
    pfam16656
    Location:34124
    Pur_ac_phosph_N; Purple acid Phosphatase, N-terminal domain

RNA

  1. XR_001753684.2 RNA Sequence

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