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Hsp23 Heat shock protein 23 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39077, updated on 6-Jul-2026
Official Symbol
Hsp23provided by FlyBase
Official Full Name
Heat shock protein 23provided by FlyBase
Primary source
FLYBASE:FBgn0001224
Locus tag
Dmel_CG4463
See related
AllianceGenome:FB:FBgn0001224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
23; CG4463; Dmel20.6; Dmel\CG4463; DmHsp23; DmHSP23; hsp 22K; hsp 23; hsp 23K; hsp-23; Hsp-23; hsp23; HSP23; hsp23/22; HSP23/IAP; small hsp locus 67B
Summary
Enables unfolded protein binding activity. Involved in several processes, including cold acclimation; protein folding; and response to heat. Located in cytosol. Is expressed in several structures, including adult head; adult heart; ganglia; primary neurons; and somatic precursor cell. Human ortholog(s) of this gene implicated in cataract 16 multiple types; cataract 9 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAA (crystallin alpha A) and CRYAB (crystallin alpha B). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See Hsp23 in Genome Data Viewer
Location:
67B3-67B3; 3-29 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9381882..9382765)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9374982..9375865)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 26 Neighboring gene antisense RNA:CR43481 Neighboring gene Heat shock gene 67Ba Neighboring gene Heat shock protein 27 Neighboring gene pseudo Neighboring gene pseudo

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Maternal loading of a small heat shock protein increases embryo thermal tolerance in Drosophila melanogaster. Lockwood BL, et al. J Exp Biol, 2017 Dec 1. PMID 29097593, Free PMC Article
  2. Drosophila melanogaster is polymorphic for a specific repeated (CATA) sequence in the regulatory region of hsp23. Frydenberg J, et al. Gene, 1999 Aug 20. PMID 10452944
  3. Genomic knockout of hsp23 both decreases and increases fitness under opposing thermal extremes in Drosophila melanogaster. Gu X, et al. Insect Biochem Mol Biol, 2021 Dec. PMID 34562590
  4. Heat shock and ecdysterone activation of the Drosophila melanogaster hsp23 gene; a sequence element implied in developmental regulation. Mestril R, et al. EMBO J, 1986 Jul. PMID 3091364, Free PMC Article
  5. Identification of a sequence element in the promoter of the Drosophila melanogaster hsp23 gene that is required for its heat activation. Mestril R, et al. EMBO J, 1985 Nov. PMID 2998770, Free PMC Article

See all (292) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genomic knockout of hsp23 both decreases and increases fitness under opposing thermal extremes in Drosophila melanogaster.
    Title: Genomic knockout of hsp23 both decreases and increases fitness under opposing thermal extremes in Drosophila melanogaster.
  2. Small heat shock proteins determine synapse number and neuronal activity during development.
    Title: Small heat shock proteins determine synapse number and neuronal activity during development.
  3. Hsp22 and Hsp23 play important roles in the recovery from chill coma in adult males, and suggest that these contribute to adaptive responses to fluctuating thermal conditions.
    Title: Knocking down expression of Hsp22 and Hsp23 by RNA interference affects recovery from chill coma in Drosophila melanogaster.
  4. The data demonstrate a specific over-expression phenotype for hsp22 and suggest that hsp22 interacts with heat and oxidative stress resistance pathways.
    Title: Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster.
  5. We conclude that histone acetylation stimulates the transcription initiation and promotes the transcription elongation, thereby up-regulating both basal and inducible expression of hsp22 in D. melanogaster.
    Title: Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein holdase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein holdase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in cold acclimation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein refolding ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
heat shock protein 23
Names
CG4463-PA
CG4463-PB
Hsp 23
Hsp23-PA
Hsp23-PB
heat-shock protein 23
protein 23

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9381882..9382765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259765.2 → NP_001246694.1  heat shock protein 23, isoform B

    See identical proteins and their annotated locations for NP_001246694.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02516, Q9VSX5
    UniProtKB/TrEMBL
    M9NE68
    Conserved Domains (2) summary
    cd06526
    Location:67 → 145
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    COG0071
    Location:69 → 161
    IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]

  2. NM_079275.4 → NP_523999.1  heat shock protein 23, isoform A

    See identical proteins and their annotated locations for NP_523999.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02516, Q9VSX5
    UniProtKB/TrEMBL
    M9NE68
    Related
    FBpp0076181
    Conserved Domains (2) summary
    cd06526
    Location:67 → 145
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    COG0071
    Location:69 → 161
    IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NE68 M9NE68
P02516.2 P02516

Gene LinkOut

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