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CG4461 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39074, updated on 2-Nov-2024

Summary

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Official Symbol
CG4461provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035982
Locus tag
Dmel_CG4461
See related
AllianceGenome:FB:FBgn0035982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
148460_at; 4461; BEST:GH12586; DmCG4461; Dmel23.8; Dmel\CG4461; gh12586; Hsp20
Summary
Predicted to enable unfolded protein binding activity. Involved in response to heat. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG4461 in Genome Data Viewer
Location:
67B2-67B2; 3-29 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9375430..9376293)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9368530..9369393)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Heat shock gene 67Bc Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 22 Neighboring gene Heat shock protein 26 Neighboring gene antisense RNA:CR43481 Neighboring gene Heat shock gene 67Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the shsp genes in Drosophila buzzatii and association between the frequency of Valine mutations in hsp23 and climatic variables along a longitudinal gradient in Australia. Frydenberg J, et al. Cell Stress Chaperones, 2010 May. PMID 19806471, Free PMC Article
  2. Effects of different small HSPB members on contractile dysfunction and structural changes in a Drosophila melanogaster model for Atrial Fibrillation. Zhang D, et al. J Mol Cell Cardiol, 2011 Sep. PMID 21745477
  3. Coincidence of P-insertion sites and breakpoints of deletions induced by activating P elements in Drosophila. Sudi J, et al. Genetics, 2008 May. PMID 18493052, Free PMC Article
  4. Drosophila small heat shock proteins: cell and organelle-specific chaperones? Michaud S, et al. Prog Mol Subcell Biol, 2002. PMID 11908067
  5. Specific protein homeostatic functions of small heat-shock proteins increase lifespan. Vos MJ, et al. Aging Cell, 2016 Apr. PMID 26705243, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4461-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9375430..9376293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140047.2 → NP_648304.1  uncharacterized protein Dmel_CG4461 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648304.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSX2
    Related
    FBpp0076180
    Conserved Domains (1) summary
    cd06526
    Location:94 → 169
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSX2 Q9VSX2

Gene LinkOut

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