U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hsp67Bc Heat shock gene 67Bc [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39071, updated on 2-Nov-2024

Summary

Official Symbol
Hsp67Bcprovided by FlyBase
Official Full Name
Heat shock gene 67Bcprovided by FlyBase
Primary source
FLYBASE:FBgn0001229
Locus tag
Dmel_CG4190
See related
AllianceGenome:FB:FBgn0001229
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4190; Dm-HSP67Bc; Dmel18.0; Dmel\CG4190; gene 3; gene-3; gene3; gene5; Hsp-G3; HSP67; hsp67B; hsp67bc; hsp67Bc; Hsp67BC; HSP67Bc; HSP67BC; HspB8; HSPB8; Hspg3; small hsp locus 67B
Summary
Predicted to enable unfolded protein binding activity. Involved in regulation of autophagy; regulation of protein metabolic process; and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including embryonic head sensory system; ganglia; sensory nervous system primordium; and yolk nucleus. Used to study Charcot-Marie-Tooth disease axonal type 2L and autosomal dominant distal hereditary motor neuronopathy 2. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hsp67Bc in Genome Data Viewer
Location:
67B2-67B2; 3-29 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9371511..9372497, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9364611..9365597, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 67A Neighboring gene mitochondrial ribosome recycling factor 1 Neighboring gene uncharacterized protein Neighboring gene Ferredoxin 1 Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 22 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding ISM
Inferred from Sequence Model
more info
PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding ISM
Inferred from Sequence Model
more info
PubMed 
involved_in positive regulation of protein lipidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to heat IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
heat shock gene 67Bc
Names
CG4190-PA
Hsp67Bc-PA
gene 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9371511..9372497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079270.3NP_523994.1  heat shock gene 67Bc [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P22979, Q4V3R7, Q9VSW9
    Related
    FBpp0076225
    Conserved Domains (2) summary
    cd06526
    Location:75154
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    COG0071
    Location:79170
    IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]