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C1QTNF8 C1q and TNF related 8 [ Homo sapiens (human) ]

Gene ID: 390664, updated on 12-Aug-2022

Summary

Official Symbol
C1QTNF8provided by HGNC
Official Full Name
C1q and TNF related 8provided by HGNC
Primary source
HGNC:HGNC:31374
See related
Ensembl:ENSG00000184471 MIM:614147; AllianceGenome:HGNC:31374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRP8; UNQ5829
Summary
Involved in positive regulation of cell motility. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See C1QTNF8 in Genome Data Viewer
Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1088226..1096306, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1099983..1108561, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1138226..1146244, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13654 Neighboring gene SSTR5 antisense RNA 1 Neighboring gene somatostatin receptor 5 Neighboring gene uncharacterized LOC107984906 Neighboring gene 16p subtelomeric meiotic recombination hotspot Neighboring gene uncharacterized LOC105371042

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell motility IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complement C1q tumor necrosis factor-related protein 8
Names
C1q and tumor necrosis factor related protein 8
C1q/TNF-related protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207419.3NP_997302.2  complement C1q tumor necrosis factor-related protein 8 precursor

    See identical proteins and their annotated locations for NP_997302.2

    Status: VALIDATED

    Source sequence(s)
    AC009041, AL031713
    Consensus CDS
    CCDS32358.1
    UniProtKB/Swiss-Prot
    B7U178, P60827
    UniProtKB/TrEMBL
    A0A3B0IWW5
    Related
    ENSP00000330426.5, ENST00000328449.6
    Conserved Domains (2) summary
    pfam01391
    Location:69111
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:118246
    C1q; C1q domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1088226..1096306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434100.1XP_047290056.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178
    UniProtKB/TrEMBL
    A0A3B0IWW5
  2. XM_047434099.1XP_047290055.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178
    UniProtKB/TrEMBL
    A0A3B0IWW5
  3. XM_047434101.1XP_047290057.1  complement C1q tumor necrosis factor-related protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B7U178
    UniProtKB/TrEMBL
    A0A3B0IWW5

RNA

  1. XR_001751901.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1099983..1108561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)