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RNASE9 ribonuclease A family member 9 (inactive) [ Homo sapiens (human) ]

Gene ID: 390443, updated on 17-Jun-2019

Summary

Official Symbol
RNASE9provided by HGNC
Official Full Name
ribonuclease A family member 9 (inactive)provided by HGNC
Primary source
HGNC:HGNC:20673
See related
Ensembl:ENSG00000188655 MIM:614014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAK1; h461; HEL128
Orthologs

Genomic context

See RNASE9 in Genome Data Viewer
Location:
14q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20556093..20560931, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21024252..21029125, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 2 pseudogene 1 Neighboring gene SET pseudogene 1 Neighboring gene ribonuclease A family member 11 (inactive) Neighboring gene uncharacterized LOC254028 Neighboring gene ribonuclease A family member 12 (inactive) Neighboring gene tRNA-Pro (anticodon AGG) 2-5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT ribonuclease activity IKR
Inferred from Key Residues
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inactive ribonuclease-like protein 9
Names
ribonuclear enzyme
ribonuclease A K1
ribonuclease, RNase A family, 9 (non-active)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001673.3NP_001001673.2  inactive ribonuclease-like protein 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001001673.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 5, 6, 7, and 8 encode the same isoform (2).
    Source sequence(s)
    AY907670
    Consensus CDS
    CCDS32036.1
    UniProtKB/Swiss-Prot
    P60153
    UniProtKB/TrEMBL
    W0UV99
    Related
    ENSP00000340162.3, ENST00000338904.7
    Conserved Domains (1) summary
    cd00163
    Location:61174
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  2. NM_001110356.1NP_001103826.1  inactive ribonuclease-like protein 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001103826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as alpha2) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 5, 6, 7, and 8 encode the same isoform (2).
    Source sequence(s)
    EF061297
    Consensus CDS
    CCDS32036.1
    UniProtKB/Swiss-Prot
    P60153
    UniProtKB/TrEMBL
    W0UV99
    Related
    ENSP00000450599.1, ENST00000554964.5
    Conserved Domains (1) summary
    cd00163
    Location:61174
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  3. NM_001110357.1NP_001103827.1  inactive ribonuclease-like protein 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001103827.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6, also known as alpha1) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 5, 6, 7, and 8 encode the same isoform (2).
    Source sequence(s)
    EF061296
    Consensus CDS
    CCDS32036.1
    UniProtKB/Swiss-Prot
    P60153
    UniProtKB/TrEMBL
    W0UV99
    Related
    ENSP00000409504.2, ENST00000429244.6
    Conserved Domains (1) summary
    cd00163
    Location:61174
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  4. NM_001110358.1NP_001103828.1  inactive ribonuclease-like protein 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as alpha23) lacks an exon in the 5' UTR and uses an alternate splice site in the 5' coding region, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (1).
    Source sequence(s)
    EF061299
    Consensus CDS
    CCDS55904.1
    UniProtKB/Swiss-Prot
    P60153
    Related
    ENSP00000450987.1, ENST00000557209.1
    Conserved Domains (1) summary
    cd00163
    Location:66179
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  5. NM_001110359.1NP_001103829.1  inactive ribonuclease-like protein 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as alpha123') represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, 3, and 4 encode the same isoform (1).
    Source sequence(s)
    EF061302
    Consensus CDS
    CCDS53883.1
    UniProtKB/Swiss-Prot
    P60153
    Related
    ENSP00000384683.3, ENST00000404716.7
    Conserved Domains (1) summary
    cd00163
    Location:66179
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  6. NM_001110360.1NP_001103830.1  inactive ribonuclease-like protein 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as alpha23') lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (1).
    Source sequence(s)
    EF061300
    Consensus CDS
    CCDS53883.1
    UniProtKB/Swiss-Prot
    P60153
    Related
    ENSP00000451160.1, ENST00000556208.5
    Conserved Domains (1) summary
    cd00163
    Location:66179
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  7. NM_001110361.1NP_001103831.1  inactive ribonuclease-like protein 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001103831.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as alpha123) uses an alternate splice site in the 5' coding region, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (1).
    Source sequence(s)
    EF061301
    Consensus CDS
    CCDS55904.1
    UniProtKB/Swiss-Prot
    P60153
    Related
    ENSP00000450570.1, ENST00000553706.5
    Conserved Domains (1) summary
    cd00163
    Location:66179
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  8. NM_001289110.1NP_001276039.1  inactive ribonuclease-like protein 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001276039.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 5, 6, 7, and 8 encode the same isoform (2).
    Source sequence(s)
    EF061298
    Consensus CDS
    CCDS32036.1
    UniProtKB/Swiss-Prot
    P60153
    UniProtKB/TrEMBL
    W0UV99
    Related
    ENSP00000451285.1, ENST00000553541.5
    Conserved Domains (1) summary
    cd00163
    Location:61174
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20556093..20560931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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