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OR4N2 olfactory receptor family 4 subfamily N member 2 [ Homo sapiens (human) ]

Gene ID: 390429, updated on 22-Sep-2022

Summary

Official Symbol
OR4N2provided by HGNC
Official Full Name
olfactory receptor family 4 subfamily N member 2provided by HGNC
Primary source
HGNC:HGNC:14742
See related
Ensembl:ENSG00000176294 AllianceGenome:HGNC:14742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR14-8; OR14-13
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Mar 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OR4N2 in Genome Data Viewer
Location:
14q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (19803770..19830253)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14003230..14029714)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20271929..20298412)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily M member 1 Neighboring gene olfactory receptor family 4 subfamily N member 1 pseudogene Neighboring gene olfactory receptor family 4 subfamily K member 6 pseudogene Neighboring gene olfactory receptor family 4 subfamily K member 3 (gene/pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 4N2
Names
olfactory receptor OR14-13
olfactory receptor OR14-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034035.1 RefSeqGene

    Range
    5001..31484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001004723.3NP_001004723.1  olfactory receptor 4N2

    See identical proteins and their annotated locations for NP_001004723.1

    Status: VALIDATED

    Source sequence(s)
    AL391156
    Consensus CDS
    CCDS32022.1
    UniProtKB/Swiss-Prot
    Q6IFA2, Q8NGD1
    UniProtKB/TrEMBL
    A0A126GVT2
    Related
    ENSP00000452022.2, ENST00000557677.3
    Conserved Domains (2) summary
    pfam00001
    Location:41287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35302
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    19803770..19830253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791796.1 Reference GRCh38.p14 PATCHES

    Range
    6452..32935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    14003230..14029714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)