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Doc2 Dorsocross2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39038, updated on 31-Mar-2026
Official Symbol
Doc2provided by FlyBase
Official Full Name
Dorsocross2provided by FlyBase
Primary source
FLYBASE:FBgn0035956
Locus tag
Dmel_CG5187
See related
AllianceGenome:FB:FBgn0035956
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5187; Dm-DOC2; Dmel\CG5187; doc; Doc; Doc-2; doc2
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in anterior Malpighian tubule development; cardiocyte differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; epithelium; germ layer; head epidermis primordium; and trunk visceral muscle primordium. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 5. Orthologous to human TBX6 (T-box transcription factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Doc2 in Genome Data Viewer
Location:
66F1-66F1; 3-28 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9012686..9019246, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9005786..9012346, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dorsocross3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46451 Neighboring gene Dorsocross1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. BAC clones generated from sheared DNA. Osoegawa K, et al. Genomics, 2007 Feb. PMID 17098394, Free PMC Article
  2. Multiple parameters shape the 3D chromatin structure of single nuclei at the doc locus in Drosophila. Götz M, et al. Nat Commun, 2022 Sep 14. PMID 36104317, Free PMC Article
  3. T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner. Fan Z, et al. Insect Biochem Mol Biol, 2021 Feb. PMID 33412239
  4. Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster. Wang J, et al. Mol Cell Biol, 2005 May. PMID 15870289, Free PMC Article
  5. Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development. Espinola SM, et al. Nat Genet, 2021 Apr. PMID 33795867

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner.
    Title: T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner.
  2. results suggest that Doc regulates the expression of Delta and influence the outcome of Notch signaling in the eye discs
    Title: Regulation of Notch signaling in the developing Drosophila eye by a T-box containing transcription factor, Dorsocross.
  3. Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc
    Title: The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc.
  4. Dorsocross genes are required for normal patterning of the dorsolateral ectoderm and, in particular, the repression of wingless and the ladybird homeobox genes within this area of the germ band
    Title: The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp.
  5. Required for the formation of all myocardial and pericardial cell types, with the exception of the Eve-positive pericardial cells.
    Title: The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior Malpighian tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cardiocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_positive_effect imaginal disc fusion, thorax closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Dorsocross2
Names
CG5187-PA
Doc2-PA
dorsocross

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9012686..9019246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140025.4 → NP_648282.1  Dorsocross2

    See identical proteins and their annotated locations for NP_648282.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VST2
    Related
    FBpp0076274
    Conserved Domains (1) summary
    cd00182
    Location:55 → 242
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VST2 Q9VST2

Gene LinkOut

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