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smg smaug [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39034, updated on 4-Jan-2025

Summary

Official Symbol
smgprovided by FlyBase
Official Full Name
smaugprovided by FlyBase
Primary source
FLYBASE:FBgn0016070
Locus tag
Dmel_CG5263
See related
AllianceGenome:FB:FBgn0016070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-D69; anonD69; CG5263; D69; Dmel\CG5263; Smaug; Smg; SmG; SMG
Summary
Enables myosin binding activity and translation repressor activity. Involved in establishment of RNA localization; negative regulation of translation; and positive regulation of mRNA catabolic process. Located in P-body. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; germline cell; and head epidermis primordium. Orthologous to human SAMD4A (sterile alpha motif domain containing 4A) and SAMD4B (sterile alpha motif domain containing 4B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See smg in Genome Data Viewer
Location:
66F1-66F1; 3-28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8990317..8997989, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8983417..8991089, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Galactokinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dorsocross3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding TAS
Traceable Author Statement
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding TAS
Traceable Author Statement
more info
PubMed 
enables mRNA regulatory element binding translation repressor activity TAS
Traceable Author Statement
more info
PubMed 
enables myosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation repressor activity IEA
Inferred from Electronic Annotation
more info
 
enables translation repressor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
smaug
Names
CG5263-PA
CG5263-PB
CG5263-PC
CG5263-PD
CG5263-PE
SMAUG
dSmaug
smau
smg-PA
smg-PB
smg-PC
smg-PD
smg-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8990317..8997989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168309.3NP_729441.1  smaug, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729441.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1P7, B7Z0F4, B7Z0F5, Q23972, Q9V3T0, Q9VSS8
    Related
    FBpp0076276
    Conserved Domains (3) summary
    cd09557
    Location:597655
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:601656
    SAM; Sterile alpha motif
    pfam09246
    Location:656763
    PHAT; PHAT
  2. NM_079263.3NP_523987.1  smaug, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523987.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1P7, B7Z0F4, B7Z0F5, Q23972, Q9V3T0, Q9VSS8
    Related
    FBpp0076277
    Conserved Domains (3) summary
    cd09557
    Location:597655
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:601656
    SAM; Sterile alpha motif
    pfam09246
    Location:656763
    PHAT; PHAT
  3. NM_001144452.2NP_001137924.1  smaug, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137924.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23972
    Conserved Domains (3) summary
    cd09557
    Location:597655
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:601656
    SAM; Sterile alpha motif
    pfam09246
    Location:656763
    PHAT; PHAT
  4. NM_168310.3NP_729442.1  smaug, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729442.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1P7, B7Z0F4, B7Z0F5, Q23972, Q9V3T0, Q9VSS8
    Related
    FBpp0076278
    Conserved Domains (3) summary
    cd09557
    Location:597655
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:601656
    SAM; Sterile alpha motif
    pfam09246
    Location:656763
    PHAT; PHAT
  5. NM_001144453.2NP_001137925.1  smaug, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137925.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1P7, B7Z0F4, B7Z0F5, Q23972, Q9V3T0, Q9VSS8
    Conserved Domains (3) summary
    cd09557
    Location:597655
    SAM_Smaug; SAM domain of Smaug subfamily
    smart00454
    Location:601656
    SAM; Sterile alpha motif
    pfam09246
    Location:656763
    PHAT; PHAT