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OR8A1 olfactory receptor family 8 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 390275, updated on 22-Aug-2020

Summary

Official Symbol
OR8A1provided by HGNC
Official Full Name
olfactory receptor family 8 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:8469
See related
Ensembl:ENSG00000196119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OST025; OR11-318
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See OR8A1 in Genome Data Viewer
Location:
11q24.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (124569997..124571374)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124439965..124440945)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 8 subfamily B member 3 pseudogene Neighboring gene olfactory receptor family 8 subfamily B member 12 Neighboring gene olfactory receptor family 8 subfamily Q member 1 pseudogene Neighboring gene pannexin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide and gene-based association studies of anxiety disorders in European and african american samples.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 8A1
Names
olfactory receptor OR11-318

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005194.2NP_001005194.2  olfactory receptor 8A1

    Status: VALIDATED

    Source sequence(s)
    BC137197, BI093413
    Consensus CDS
    CCDS31712.1
    Related
    ENSP00000284287.4, ENST00000284287.6
    Conserved Domains (2) summary
    cd14964
    Location:2751
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:16304
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    124569997..124571374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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