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KDM4E lysine demethylase 4E [ Homo sapiens (human) ]

Gene ID: 390245, updated on 17-Jun-2024

Summary

Official Symbol
KDM4Eprovided by HGNC
Official Full Name
lysine demethylase 4Eprovided by HGNC
Primary source
HGNC:HGNC:37098
See related
Ensembl:ENSG00000235268 MIM:616581; AllianceGenome:HGNC:37098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KDM5E; JMJD2E; KDM4DL
Summary
The protein encoded by this intronless gene is a member of a large family of histone lysine demethylases, which use oxygen and 2-oxoglutarate to demethylate di- and trimethylated lys9 of histone H3. Derepression of genes by demethylases is sometimes involved in viral infection or carcinogenesis, so inhibitors of these enzymes are desired. [provided by RefSeq, Dec 2016]
Orthologs
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Genomic context

See KDM4E in Genome Data Viewer
Location:
11q21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (95025258..95027596)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (95032295..95034633)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94758422..94760760)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene lysine demethylase 4D Neighboring gene general transcription factor IIE subunit 2 pseudogene Neighboring gene lysine demethylase 4D pseudogene Neighboring gene lysine demethylase 4D pseudogene Neighboring gene serine and arginine rich splicing factor 8B, pseudogene

Genomic regions, transcripts, and products

General gene information

Clone Names

  • MGC189713, MGC189746, MGC198631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H3K9 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3K9me2/H3K9me3 demethylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lysine-specific demethylase 4E
Names
KDM4D-like protein
[histone H3]-trimethyl-L-lysine(9) demethylase 4E
lysine (K)-specific demethylase 4E
NP_001155102.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053123.1 RefSeqGene

    Range
    5001..7339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161630.1NP_001155102.1  lysine-specific demethylase 4E

    See identical proteins and their annotated locations for NP_001155102.1

    Status: REVIEWED

    Source sequence(s)
    BC157851
    Consensus CDS
    CCDS44713.1
    UniProtKB/Swiss-Prot
    B2RXH2
    Related
    ENSP00000397239.2, ENST00000450979.2
    Conserved Domains (2) summary
    pfam02373
    Location:176292
    JmjC; JmjC domain, hydroxylase
    pfam02375
    Location:1650
    JmjN; jmjN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    95025258..95027596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    95032295..95034633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)