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IZUMO1R IZUMO1 receptor, JUNO [ Homo sapiens (human) ]

Gene ID: 390243, updated on 13-Mar-2020

Summary

Official Symbol
IZUMO1Rprovided by HGNC
Official Full Name
IZUMO1 receptor, JUNOprovided by HGNC
Primary source
HGNC:HGNC:32565
See related
Ensembl:ENSG00000183560 MIM:615737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JUNO; FOLR4; Folbp3; FR-delta
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IZUMO1R in Genome Data Viewer
Location:
11q21
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (94304739..94308146)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94038803..94040858)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369435 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 3 Neighboring gene G protein-coupled receptor 83 Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene microRNA 548l

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT folic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
fusion of sperm to egg plasma membrane involved in single fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
single fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
sperm-egg recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
anchored component of external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sperm-egg fusion protein Juno
Names
IZUMO1 receptor protein JUNO
IZUMO1 receptor, JUNO, FR-delta
folate receptor 4 (delta) homolog
folate receptor 4, delta (putative)
folate receptor delta
probable folate receptor delta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199206.3NP_001186135.1  sperm-egg fusion protein Juno precursor

    See identical proteins and their annotated locations for NP_001186135.1

    Status: VALIDATED

    Source sequence(s)
    AP002784
    Consensus CDS
    CCDS81615.1
    UniProtKB/Swiss-Prot
    A6ND01
    UniProtKB/TrEMBL
    J3KNP7
    Related
    ENSP00000332963.5, ENST00000328458.5
    Conserved Domains (1) summary
    pfam03024
    Location:27208
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    94304739..94308146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080486.1: Suppressed sequence

    Description
    NM_001080486.1: This RefSeq was permanently suppressed because currently there is insufficient human transcript support.
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