ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like [Homo sapiens (human)] - Gene

Summary

Official Symbol: ACCSLprovided by HGNC
Official Full Name: 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) likeprovided by HGNC
Primary source: HGNC:HGNC:34391
See related: Ensembl:ENSG00000205126
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 11p11.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109.20211119	current	GRCh38.p13 (GCF_000001405.39)	11	NC_000011.10 (44047981..44059977)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (44069531..44081527)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the ACCSL gene: The ACCSL gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 112 organisms have orthologs with human gene ACCSL
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular amino acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2

Names: 1-aminocyclopropane-1-carboxylate synthase (inactive)-like; 1-aminocyclopropane-1-carboxylate synthase homolog(non-functional)-like; 1-aminocyclopropane-1-carboxylate synthase-like protein 2; ACC synthase-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031854.2 → NP_001027025.2 probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 1

See identical proteins and their annotated locations for NP_001027025.2

Status: VALIDATED

Source sequence(s)

AB231732, AB231733, AB231734, AC134775, DW009984

Consensus CDS

CCDS41636.1

UniProtKB/Swiss-Prot

Q4AC99

UniProtKB/TrEMBL

Q3C1W0

Related

ENSP00000368109.1, ENST00000378832.1

Conserved Domains (2) summary

cd00609
Location:171 → 546

AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

PLN02607
Location:150 → 561

PLN02607; 1-aminocyclopropane-1-carboxylate synthase
NM_001363113.1 → NP_001350042.1 probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC134775

Conserved Domains (1) summary

cl27741
Location:17 → 380

Aminotran_1_2; Aminotransferase class I and II