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ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like [ Homo sapiens (human) ]

Gene ID: 390110, updated on 5-Jul-2025
Official Symbol
ACCSLprovided by HGNC
Official Full Name
1-aminocyclopropane-1-carboxylate synthase homolog (inactive) likeprovided by HGNC
Primary source
HGNC:HGNC:34391
See related
Ensembl:ENSG00000205126 AllianceGenome:HGNC:34391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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See ACCSL in Genome Data Viewer
Location:
11p11.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (43921068..44059977)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (44076427..44215307)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44069531..44081527)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene alkB homolog 3, alpha-ketoglutarate dependent dioxygenase Neighboring gene SEC14 like 1 pseudogene 1 Neighboring gene ALKBH3 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:43941776-43942975 Neighboring gene uncharacterized LOC124902663 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43949635-43950136 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:43955407-43955585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43964814-43965643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43965644-43966472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43968482-43968982 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:43977126-43977352 Neighboring gene chromosome 11 open reading frame 96 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44003904-44004404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44004405-44004905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44026425-44027286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:44028815-44029314 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:44035825-44036324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4649 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4650 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4652 Neighboring gene exostosin glycosyltransferase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44199715-44200215 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:44218806-44220005

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Names
1-aminocyclopropane-1-carboxylate synthase (inactive)-like
1-aminocyclopropane-1-carboxylate synthase homolog(non-functional)-like
1-aminocyclopropane-1-carboxylate synthase-like protein 2
ACC synthase-like protein 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031854.2NP_001027025.2  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001027025.2

    Status: VALIDATED

    Source sequence(s)
    AB231732, AB231733, AB231734, AC134775, DW009984
    Consensus CDS
    CCDS41636.1
    UniProtKB/Swiss-Prot
    Q4AC99
    Related
    ENSP00000368109.1, ENST00000378832.1
    Conserved Domains (2) summary
    cd00609
    Location:171546
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02607
    Location:150561
    PLN02607; 1-aminocyclopropane-1-carboxylate synthase
  2. NM_001363113.1NP_001350042.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134775
    Conserved Domains (1) summary
    cl27741
    Location:17380
    Aminotran_1_2; Aminotransferase class I and II

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    43921068..44059977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426927.1XP_047282883.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    44076427..44215307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368742.1XP_054224717.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform X1