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ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like [ Homo sapiens (human) ]

Gene ID: 390110, updated on 22-Sep-2022

Summary

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Official Symbol
ACCSLprovided by HGNC
Official Full Name
1-aminocyclopropane-1-carboxylate synthase homolog (inactive) likeprovided by HGNC
Primary source
HGNC:HGNC:34391
See related
Ensembl:ENSG00000205126 AllianceGenome:HGNC:34391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable catalytic activity and pyridoxal phosphate binding activity. Predicted to be involved in biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See ACCSL in Genome Data Viewer
Location:
11p11.2
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (43921068..44059977)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (44203315..44215307)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44069531..44081527)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene alkB homolog 3, alpha-ketoglutarate dependent dioxygenase Neighboring gene SEC14 like 1 pseudogene 1 Neighboring gene ALKBH3 antisense RNA 1 Neighboring gene uncharacterized LOC124902663 Neighboring gene chromosome 11 open reading frame 96 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Neighboring gene exostosin glycosyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Names
1-aminocyclopropane-1-carboxylate synthase (inactive)-like
1-aminocyclopropane-1-carboxylate synthase homolog(non-functional)-like
1-aminocyclopropane-1-carboxylate synthase-like protein 2
ACC synthase-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031854.2 → NP_001027025.2  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001027025.2

    Status: VALIDATED

    Source sequence(s)
    AB231732, AB231733, AB231734, AC134775, DW009984
    Consensus CDS
    CCDS41636.1
    UniProtKB/Swiss-Prot
    Q4AC99
    UniProtKB/TrEMBL
    Q3C1W0
    Related
    ENSP00000368109.1, ENST00000378832.1
    Conserved Domains (2) summary
    cd00609
    Location:171 → 546
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02607
    Location:150 → 561
    PLN02607; 1-aminocyclopropane-1-carboxylate synthase

  2. NM_001363113.1 → NP_001350042.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134775
    Conserved Domains (1) summary
    cl27741
    Location:17 → 380
    Aminotran_1_2; Aminotransferase class I and II

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    43921068..44059977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426927.1 → XP_047282883.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    44203315..44215307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4AC99.3 GenPept UniProtKB/Swiss-Prot:Q4AC99

Gene LinkOut

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