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OR51B6 olfactory receptor family 51 subfamily B member 6 [ Homo sapiens (human) ]

Gene ID: 390058, updated on 22-Sep-2022

Summary

Official Symbol
OR51B6provided by HGNC
Official Full Name
olfactory receptor family 51 subfamily B member 6provided by HGNC
Primary source
HGNC:HGNC:19600
See related
Ensembl:ENSG00000176239 AllianceGenome:HGNC:19600
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOR5'Beta6
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR51B6 in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5351508..5352446)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5410842..5411780)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5372738..5373676)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily B member 2 Neighboring gene olfactory receptor family 51 subfamily B member 8 pseudogene Neighboring gene amphiphysin pseudogene Neighboring gene olfactory receptor family 51 subfamily B member 5 Neighboring gene TMEM258 pseudogene 1

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
EBI GWAS Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 51B6
Names
odorant receptor HOR5'beta6
olfactory receptor 51B5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004750.1NP_001004750.1  olfactory receptor 51B6

    See identical proteins and their annotated locations for NP_001004750.1

    Status: PROVISIONAL

    Source sequence(s)
    AC104389
    Consensus CDS
    CCDS31379.1
    UniProtKB/Swiss-Prot
    Q9H340
    Related
    ENSP00000369568.1, ENST00000380219.1
    Conserved Domains (2) summary
    pfam00001
    Location:39290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31306
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    5351508..5352446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    5410842..5411780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)