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NKX1-2 NK1 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 390010, updated on 18-Aug-2020

Summary

Official Symbol
NKX1-2provided by HGNC
Official Full Name
NK1 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:31652
See related
Ensembl:ENSG00000229544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKX-1.1; C10orf121; bB238F13.2
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NKX1-2 in Genome Data Viewer
Location:
10q26.13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (124445243..124450035, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (126135998..126138550, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ornithine aminotransferase Neighboring gene ornithine aminotransferase pseudogene 1 Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene ribosomal protein S10 pseudogene 18 Neighboring gene uncharacterized LOC105378539 Neighboring gene family with sequence similarity 53 member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NK1 transcription factor-related protein 2
Names
NK1 transcription factor related, locus 2
homeobox protein SAX-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146340.3NP_001139812.1  NK1 transcription factor-related protein 2

    See identical proteins and their annotated locations for NP_001139812.1

    Status: VALIDATED

    Source sequence(s)
    AL445237, BX092002
    Consensus CDS
    CCDS59221.1
    UniProtKB/Swiss-Prot
    Q9UD57
    Related
    ENSP00000451945.1, ENST00000451024.5
    Conserved Domains (1) summary
    pfam00046
    Location:167219
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    124445243..124450035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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