U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NKX1-2 NK1 homeobox 2 [ Homo sapiens (human) ]

Gene ID: 390010, updated on 13-May-2022

Summary

Official Symbol
NKX1-2provided by HGNC
Official Full Name
NK1 homeobox 2provided by HGNC
Primary source
HGNC:HGNC:31652
See related
Ensembl:ENSG00000229544 AllianceGenome:HGNC:31652
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKX-1.1; C10orf121; bB238F13.2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NKX1-2 in Genome Data Viewer
Location:
10q26.13
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (124445243..124450035, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (125323458..125328250, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (126133812..126138604, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 15365 Neighboring gene ornithine aminotransferase Neighboring gene ornithine aminotransferase pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 8895 Neighboring gene phospholysine phosphohistidine inorganic pyrophosphate phosphatase Neighboring gene ribosomal protein S10 pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NK1 transcription factor-related protein 2
Names
NK1 transcription factor related, locus 2
homeobox protein SAX-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146340.3NP_001139812.1  NK1 transcription factor-related protein 2

    See identical proteins and their annotated locations for NP_001139812.1

    Status: VALIDATED

    Source sequence(s)
    AL445237, BX092002
    Consensus CDS
    CCDS59221.1
    UniProtKB/Swiss-Prot
    Q9UD57
    Related
    ENSP00000451945.1, ENST00000451024.5
    Conserved Domains (1) summary
    pfam00046
    Location:167219
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    124445243..124450035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    125323458..125328250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)