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RND3 Rho family GTPase 3 [ Homo sapiens (human) ]

Gene ID: 390, updated on 5-Aug-2026
Official Symbol
RND3provided by HGNC
Official Full Name
Rho family GTPase 3provided by HGNC
Primary source
HGNC:HGNC:671
See related
Ensembl:ENSG00000115963 MIM:602924; AllianceGenome:HGNC:671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHE; Rho8; RhoE; memB
Summary
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Expression
Broad expression in esophagus (RPKM 87.1), liver (RPKM 49.1) and 19 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See RND3 in Genome Data Viewer
Location:
2q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (150468193..150487695, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (150918573..150938077, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (151324707..151344209, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tRNA-Glu (CTC) 9-1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:151267272-151268161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:151281462-151281962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:151281963-151282463 Neighboring gene uncharacterized LOC105373685 Neighboring gene Sharpr-MPRA regulatory region 9612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16628 Neighboring gene long independently transcribed non-coding RNA 1920 Neighboring gene Sharpr-MPRA regulatory region 14725 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:151476766-151477965 Neighboring gene long independently transcribed non-coding RNA 2612

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-kinase/myosin phosphatase target pathway. Ma W, et al. Hepatology, 2013 Jan. PMID 22829315
  2. Epigenetic modification of RhoE expression in gastric cancer cells. Chen J, et al. Oncol Rep, 2011 Jan. PMID 21109974
  3. Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells. Belgiovine C, et al. PLoS One, 2010 Nov 30. PMID 21209796, Free PMC Article
  4. Inhibition of microRNA-128-3p alleviates liver ischaemia-reperfusion injury in mice through repressing the Rnd3/NF-κB axis. Mou T, et al. Innate Immun, 2020 Aug. PMID 32486927, Free PMC Article
  5. [The effect of RhoE on CD44 promoter and the malignant behaviors of colorectal cancer cell]. Zhou HJ, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2011 Sep. PMID 22007478

See all (143) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3.
    Title: Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3.
  2. KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
    Title: KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
  3. Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma.
    Title: Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma.
  4. Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase Signalling.
    Title: Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase Signalling.
  5. RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway.
    Title: RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway.
  6. Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence.
    Title: Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence.
  7. HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3.
    Title: HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3.
  8. Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.
    Title: Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.
  9. Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma.
    Title: Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma.
  10. Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARgamma-UCP2 cascade.
    Title: Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARγ-UCP2 cascade.
Submit: New GeneRIF Correction See all GeneRIFs (65)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association search for type 2 diabetes genes in African Americans.
EBI GWAS Catalog
Genome-wide association study link novel loci to endometriosis.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of Rho family GTPase 3 (RND3) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding TAS
Traceable Author Statement
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
Preferred Names
rho-related GTP-binding protein RhoE
Names
protein MemB
ras homolog gene family, member E
rho-related GTP-binding protein Rho8
small GTP binding protein Rho8
NP_001241667.1
NP_005159.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001254738.1 → NP_001241667.1  rho-related GTP-binding protein RhoE precursor

    See identical proteins and their annotated locations for NP_001241667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC074097, AC093738, AK313224
    Consensus CDS
    CCDS2190.1
    UniProtKB/Swiss-Prot
    D3DP95, P52199, P61587
    UniProtKB/TrEMBL
    B2R838
    Related
    ENSP00000364886.2, ENST00000375734.6
    Conserved Domains (1) summary
    cd04172
    Location:19 → 200
    Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases

  2. NM_005168.5 → NP_005159.1  rho-related GTP-binding protein RhoE precursor

    See identical proteins and their annotated locations for NP_005159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012513, BX460517, CF127383, DC367501
    Consensus CDS
    CCDS2190.1
    UniProtKB/Swiss-Prot
    D3DP95, P52199, P61587
    UniProtKB/TrEMBL
    B2R838
    Related
    ENSP00000263895.4, ENST00000263895.9
    Conserved Domains (1) summary
    cd04172
    Location:19 → 200
    Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    150468193..150487695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    150918573..150938077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61587.1 GenPept UniProtKB/Swiss-Prot:P61587

Gene LinkOut

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