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RND3 Rho family GTPase 3 [ Homo sapiens (human) ]

Gene ID: 390, updated on 11-Sep-2019

Summary

Official Symbol
RND3provided by HGNC
Official Full Name
Rho family GTPase 3provided by HGNC
Primary source
HGNC:HGNC:671
See related
Ensembl:ENSG00000115963 MIM:602924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHE; Rho8; RhoE; memB
Summary
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Expression
Broad expression in esophagus (RPKM 87.1), liver (RPKM 49.1) and 19 other tissues See more
Orthologs

Genomic context

See RND3 in Genome Data Viewer
Location:
2q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (150468193..150487695, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (151324707..151344209, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tRNA-Glu (CTC) 9-1 Neighboring gene uncharacterized LOC105373685 Neighboring gene long intergenic non-protein coding RNA 1920 Neighboring gene long intergenic non-protein coding RNA 2612

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association search for type 2 diabetes genes in African Americans.
NHGRI GWA Catalog
Genome-wide association study link novel loci to endometriosis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of Rho family GTPase 3 (RND3) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of actin cytoskeleton polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell division site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion HDA PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rho-related GTP-binding protein RhoE
Names
protein MemB
ras homolog gene family, member E
rho-related GTP-binding protein Rho8
small GTP binding protein Rho8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001254738.1NP_001241667.1  rho-related GTP-binding protein RhoE precursor

    See identical proteins and their annotated locations for NP_001241667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC074097, AC093738, AK313224
    Consensus CDS
    CCDS2190.1
    UniProtKB/Swiss-Prot
    P61587
    UniProtKB/TrEMBL
    B2R838
    Related
    ENSP00000364886.2, ENST00000375734.6
    Conserved Domains (1) summary
    cd04172
    Location:19200
    Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases
  2. NM_005168.4NP_005159.1  rho-related GTP-binding protein RhoE precursor

    See identical proteins and their annotated locations for NP_005159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC012513, BX460517, CF127383, DC367501
    Consensus CDS
    CCDS2190.1
    UniProtKB/Swiss-Prot
    P61587
    Related
    ENSP00000263895.4, ENST00000263895.8
    Conserved Domains (1) summary
    cd04172
    Location:19200
    Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    150468193..150487695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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