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UBE2NL ubiquitin conjugating enzyme E2 N like (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 389898, updated on 23-Nov-2023

Summary

Official Symbol
UBE2NLprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 N like (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:31710
See related
Ensembl:ENSG00000276380 AllianceGenome:HGNC:31710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Li174
Summary
This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. This locus represents a polymorphic pseudogene, where some individuals contain an allele that can encode a full-length protein, while others have a non-functional allele containing a premature stop codon (reference SNP rs237520) that truncates the coding sequence. [provided by RefSeq, Jun 2014]
Annotation information
Annotation category: suggests misassembly
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
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Genomic context

See UBE2NL in Genome Data Viewer
Location:
Xq27.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (143884071..143885255)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (142189090..142190279)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (142967173..142968362)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:142809175-142809676 Neighboring gene SPANX family member N2 Neighboring gene ribonucleotide reductase M2 polypeptide pseudogene 4 Neighboring gene NANOG hESC enhancer GRCh37_chrX:143834881-143835457 Neighboring gene NANOG hESC enhancer GRCh37_chrX:143855361-143855862 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:143882879-143884078 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 10

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
NOT involved_in postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
putative ubiquitin-conjugating enzyme E2 N-like
Names
epididymis tissue protein Li 174
ubiquitin conjugating enzyme E2N-like
NP_001013007.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016268.2 RefSeqGene

    Range
    5000..6184
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012989.3NP_001013007.1  putative ubiquitin-conjugating enzyme E2 N-like

    See identical proteins and their annotated locations for NP_001013007.1

    Status: REVIEWED

    Source sequence(s)
    AL109622
    UniProtKB/Swiss-Prot
    E9KL27, Q5JXB2
    Conserved Domains (2) summary
    COG5078
    Location:7151
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cl00154
    Location:4152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

  1. NR_121210.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (non-coding) represents the non-functional allele, which contains a nonsense polymorphism (reference SNP rs237520) that truncates the coding sequence found in the coding variant.
    Source sequence(s)
    AL135920, GU727624
    Related
    ENST00000618570.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    143884071..143885255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791819.1 Reference GRCh38.p14 PATCHES

    Range
    169154..170343
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    142189090..142190279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)