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USP27X ubiquitin specific peptidase 27 X-linked [ Homo sapiens (human) ]

Gene ID: 389856, updated on 12-Oct-2019

Summary

Official Symbol
USP27Xprovided by HGNC
Official Full Name
ubiquitin specific peptidase 27 X-linkedprovided by HGNC
Primary source
HGNC:HGNC:13486
See related
Ensembl:ENSG00000273820 MIM:300975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USP27; MRX105; USP22L
Summary
This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016]
Orthologs

Genomic context

See USP27X in Genome Data Viewer
Location:
Xp11.23
Exon count:
1
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (49879484..49882558)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49644470..49647169)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene PAGE family member 4 Neighboring gene USP27X antisense RNA 1 (head to head) Neighboring gene cleavage and polyadenylation specific factor 1, 160kDa pseudogene Neighboring gene chloride voltage-gated channel 5 Neighboring gene RNA, U6 small nuclear 421, pseudogene

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Lys48-specific deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Lys63-specific deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
thiol-dependent ubiquitin-specific protease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein K63-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 27
Names
X-linked ubiquitin carboxyl-terminal hydrolase 27
deubiquitinating enzyme 27
ubiquitin specific protease 27, X chromosome
ubiquitin thioesterase 27
ubiquitin-specific-processing protease 27
NP_001138545.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053124.1 RefSeqGene

    Range
    4618..7692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145073.3NP_001138545.1  ubiquitin carboxyl-terminal hydrolase 27

    See identical proteins and their annotated locations for NP_001138545.1

    Status: REVIEWED

    Source sequence(s)
    AC236430
    Consensus CDS
    CCDS65260.1
    UniProtKB/Swiss-Prot
    A6NNY8
    Related
    ENSP00000483631.1, ENST00000621775.2
    Conserved Domains (1) summary
    cd02660
    Location:78419
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    49879484..49882558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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