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MAP3K15 mitogen-activated protein kinase kinase kinase 15 [ Homo sapiens (human) ]

Gene ID: 389840, updated on 12-May-2019

Summary

Official Symbol
MAP3K15provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 15provided by HGNC
Primary source
HGNC:HGNC:31689
See related
Ensembl:ENSG00000180815 MIM:300820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASK3; bA723P2.3
Summary
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in adrenal (RPKM 7.5), heart (RPKM 3.2) and 24 other tissues See more
Orthologs

Genomic context

See MAP3K15 in Genome Data Viewer
Location:
Xp22.12
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (19360058..19515261, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (19378174..19533379, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 48, pseudogene Neighboring gene uncharacterized LOC101928415 Neighboring gene phosphorylase kinase regulatory subunit alpha 2 Neighboring gene adhesion G protein-coupled receptor G2 Neighboring gene pyruvate dehydrogenase E1 alpha 1 subunit Neighboring gene eukaryotic translation initiation factor 5 pseudogene 2 Neighboring gene SH3 domain containing kinase binding protein 1 Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene uncharacterized LOC729609

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 15
Names
MAPK/ERK kinase kinase 15
MEK kinase 15
MEKK 15
apoptosis signal-regulating kinase 3
NP_001001671.3
XP_011543809.3
XP_011543810.3
XP_011543812.1
XP_011543813.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021184.1 RefSeqGene

    Range
    5001..160204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001671.3NP_001001671.3  mitogen-activated protein kinase kinase kinase 15

    See identical proteins and their annotated locations for NP_001001671.3

    Status: VALIDATED

    Source sequence(s)
    AK131412, AL732423, CN293540, DV080548
    Consensus CDS
    CCDS35212.2
    UniProtKB/Swiss-Prot
    Q6ZN16
    Related
    ENSP00000345629.4, ENST00000338883.8
    Conserved Domains (3) summary
    smart00220
    Location:657908
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:643908
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:136514
    DUF4071; Domain of unknown function (DUF4071)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    19360058..19515261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545508.3XP_011543810.3  mitogen-activated protein kinase kinase kinase 15 isoform X2

    Conserved Domains (2) summary
    cd06624
    Location:528793
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:10399
    DUF4071; Domain of unknown function (DUF4071)
  2. XM_011545507.3XP_011543809.3  mitogen-activated protein kinase kinase kinase 15 isoform X1

    Conserved Domains (2) summary
    cd06624
    Location:528793
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:10399
    DUF4071; Domain of unknown function (DUF4071)
  3. XM_011545510.2XP_011543812.1  mitogen-activated protein kinase kinase kinase 15 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:215466
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:201466
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:172
    DUF4071; Domain of unknown function (DUF4071)
  4. XM_011545511.2XP_011543813.1  mitogen-activated protein kinase kinase kinase 15 isoform X4

    See identical proteins and their annotated locations for XP_011543813.1

    UniProtKB/Swiss-Prot
    Q6ZN16
    Conserved Domains (2) summary
    smart00220
    Location:92343
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:78343
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
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