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NUGGC nuclear GTPase, germinal center associated [ Homo sapiens (human) ]

Gene ID: 389643, updated on 11-Jun-2021

Summary

Official Symbol
NUGGCprovided by HGNC
Official Full Name
nuclear GTPase, germinal center associatedprovided by HGNC
Primary source
HGNC:HGNC:33550
See related
Ensembl:ENSG00000189233 MIM:619088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLIPGC; C8orf80; SLIP-GC; HMFN0672
Expression
Biased expression in lymph node (RPKM 5.9), liver (RPKM 3.6) and 9 other tissues See more
Orthologs
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Genomic context

See NUGGC in Genome Data Viewer
Location:
8p21.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (28021964..28084068, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27879481..27941453, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1741 Neighboring gene scavenger receptor class A member 5 Neighboring gene uncharacterized LOC105379342 Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene uncharacterized LOC105379343 Neighboring gene delta 4-desaturase, sphingolipid 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
GeneReviews: Not available
Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.
GeneReviews: Not available

General gene information

Markers

Homology

Clone Names

  • FLJ26413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear GTPase SLIP-GC
Names
GTPase SLIP-GC
speckled-like pattern in the germinal center

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010906.2NP_001010906.1  nuclear GTPase SLIP-GC

    See identical proteins and their annotated locations for NP_001010906.1

    Status: VALIDATED

    Source sequence(s)
    AA482187, AA768146, AB075870, AC019031, AC091573, AK129923, BU429067, CF137482
    Consensus CDS
    CCDS47833.1
    UniProtKB/Swiss-Prot
    Q68CJ6
    Related
    ENSP00000408697.2, ENST00000413272.7
    Conserved Domains (1) summary
    cl21455
    Location:103182
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    28021964..28084068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544523.2XP_011542825.1  nuclear GTPase SLIP-GC isoform X1

    See identical proteins and their annotated locations for XP_011542825.1

    Conserved Domains (1) summary
    cl21455
    Location:127206
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011544524.3XP_011542826.1  nuclear GTPase SLIP-GC isoform X1

    See identical proteins and their annotated locations for XP_011542826.1

    Conserved Domains (1) summary
    cl21455
    Location:127206
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011544525.1XP_011542827.1  nuclear GTPase SLIP-GC isoform X3

  4. XM_017013403.1XP_016868892.1  nuclear GTPase SLIP-GC isoform X2

  5. XM_011544526.2XP_011542828.1  nuclear GTPase SLIP-GC isoform X4

    Conserved Domains (1) summary
    cl21455
    Location:127206
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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